Neuropeptide S receptor
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 2
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Neuropeptide S receptor
G protein-coupled receptor for neuropeptide S (NPS)15947423,16720571,16790440. Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels15312648,15947423,16720571,16790440,25714705,26865629. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction26865629. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade26865629. Inhibits cell growth in response to NPS binding15947423
Quoted from UniProt’s FUNCTION annotation for Q6W5P4 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane · Cytoplasm
Expression by cell type
Single cell type RNA, the 9 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Foveolar cells44.3 nCPM
- Brain inhibitory neurons31.7 nCPM
- Early spermatids19.6 nCPM
- Gastric progenitor cells16.7 nCPM
- Other brain neurons14.1 nCPM
- Brain excitatory neurons13.7 nCPM
- Syncytiotrophoblasts13.3 nCPM
- Myonuclei13.2 nCPM
- Adrenal medulla cells10.6 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 2
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Neuropeptide S receptor | Other named receptors | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1614052 |
| Neuropeptide S receptor | Other named receptors | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1614052 |