N-formyl peptide receptor 2
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 7
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
N-formyl peptide receptor 2
Pattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated molecular patterns (PAMPs and DAMPs)1374236,25605714,35217703. Preferentially recognizes longer peptides or peptides with specific sequences such as the phenol-soluble modulin (PSM) family of formylated peptide toxins produced by Staphylococcus aureus30098280. Ligand binding causes a conformation change that triggers signaling via G(i)/GNAI1 inhibiting adenylate cyclase activity, leading to decreased intracellular cAMP levels40080544. In addition, can recognize a variety of chemically distinct endogenous ligands including proteins and lipids besides formylpeptides and thereby plays multiple roles in inflammation. Acts as a receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). Acts also as a ceramide membrane receptor, and long-chain ceramides (C14 to C20) binding induces conformational changes that inhibits diet-induced adipose thermogenesis40080544. Participates in neuroprotection via interaction with humanin/MT-RNR2 and Amyloid-beta protein 42, product of APP11689470,35365641. Differential signaling is also defined by receptor oligomerization state. Binding of ANXA1 to FPR2 homodimer elicits activation of p38 MAPKinase pathway leading to HSPB1/HSP27 phosphorylation and IL10 production in monocytes. Whereas agonistic activation of FPR1:FPR2 heterodimers signals a proapoptotic JNK pathway in neutrophils
Quoted from UniProt’s FUNCTION annotation for P25090 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Neutrophils786.9 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- lymphoid tissue52.9 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 7
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| N-formyl peptide receptor 2 | Other named receptors | %Max (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209826 |
| N-formyl peptide receptor 2 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209826 |
| N-formyl peptide receptor 2 | Other named receptors | %Max (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209826 |
| N-formyl peptide receptor 2 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209826 |
| N-formyl peptide receptor 2 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209826 |
| N-formyl peptide receptor 2 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209827 |
| N-formyl peptide receptor 2 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209828 |