N-arachidonyl glycine receptor
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 11
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
N-arachidonyl glycine receptor
G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems21732409,26195725. Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA)16844083,24762058,26195725,27572937. Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis. Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis27994074. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis27572937. Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (By similarity). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Also participates in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity)
Quoted from UniProt’s FUNCTION annotation for Q14330 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane · Cytoplasmic vesicle membrane
Expression by cell type
Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Late spermatids301.2 nCPM
- Early spermatids231.6 nCPM
- Cardiomyocytes67.2 nCPM
- B-cells58.4 nCPM
- T-cells31.9 nCPM
- NK-cells31.4 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- lymphoid tissue36.3 nTPM
- testis12.2 nTPM
- bone marrow9.1 nTPM
II · Anatomy
Where the gene is transcribed
The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.
Brain
basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.
Measured but not drawn — this anatomogram has no outline for them: spinal cord 0.2, midbrain 0.1, pituitary gland 0.1.
Body
Square-root ramp · shared scale across both plates
Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of GPR18 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.
Brain · 3
- spinal cord0.2 nTPM
- midbrain0.1 nTPM
- pituitary gland0.1 nTPM
Peripheral and autonomic · 16
- spleen9.9 nTPM
- small intestine3.8 nTPM
- urinary bladder1.9 nTPM
- stomach 11.4 nTPM
- duodenum1.0 nTPM
- colon0.9 nTPM
- liver0.8 nTPM
- salivary gland0.8 nTPM
- lung0.7 nTPM
- thyroid gland0.4 nTPM
- heart muscle0.3 nTPM
- kidney0.3 nTPM
- smooth muscle0.1 nTPM
- adrenal gland0.1 nTPM
- pancreas0.1 nTPM
- skeletal muscle0.1 nTPM
Transcript is not protein. These are RNA levels for GPR18, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 8
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| N-arachidonyl glycine receptor | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2388873 |
| N-arachidonyl glycine receptor | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3222511 |
| N-arachidonyl glycine receptor | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3222511 |
| N-arachidonyl glycine receptor | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3222509 |
| N-arachidonyl glycine receptor | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4731302 |
| N-arachidonyl glycine receptor | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5504232 |
| N-arachidonyl glycine receptor | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL5504235 |
| N-arachidonyl glycine receptor | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2388875 |
Other measurements 3
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| N-arachidonyl glycine receptor | Other named receptors | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4731303 |
| N-arachidonyl glycine receptor | Other named receptors | Emax | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5504234 |
| N-arachidonyl glycine receptor | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL5504236 |