TargetEnzymes

N-acetylgalactosamine-6-sulfatase

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements: 4
Compounds: 1
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

GALNS_HUMANGALNSHomo sapiens

N-acetylgalactosamine-6-sulfatase

Lysosomal enzyme that hydrolyzes sulfate groups from glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S)

Quoted from UniProt’s FUNCTION annotation for P34059 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
GLB1	0.997	0.098	0.900	0.970
SUMF1	0.961	0.238	0.000	0.920
APRT	0.898	0.000	0.000	0.857
NEU1	0.830	0.287	0.000	0.770
ARSA	0.828	0.739	0.000	0.198
ZNF276	0.791	0.089	0.000	0.766
IDUA	0.783	0.000	0.000	0.772
CTSA	0.762	0.099	0.000	0.734
NAGLU	0.742	0.000	0.000	0.711
CDK10	0.741	0.000	0.000	0.725

Where it sits in the cell

Cytosol

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Lysosome

Expression by cell type

Single cell type RNA, the 4 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

Ependymal cells104.8 nCPM
Epididymal efferent duct ciliated cells95.7 nCPM
Respiratory ciliated cells85.2 nCPM
Late primary spermatocytes67 nCPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Other measurements 4

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
N-acetylgalactosamine-6-sulfatase	Enzymes	Inhibition	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4625616
N-acetylgalactosamine-6-sulfatase	Enzymes	FC	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4625617
N-acetylgalactosamine-6-sulfatase	Enzymes	FC	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4625618
N-acetylgalactosamine-6-sulfatase	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4625623

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