Multidrug resistance-associated protein 1
SLC and ABC transporters governing uptake and efflux — distinct from the monoamine transporters.
- Measurements
- 4
- Compounds
- 2
- Binding constants
- 1
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Multidrug resistance-associated protein 1
Mediates export of organic anions and drugs from the cytoplasm10064732,11114332,16230346,7961706,9281595. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics10064732,11114332,16230346,7961706,9281595. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export9281595. Hydrolyzes ATP with low efficiency16230346. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation17050692. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export36070769. Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway36070769. Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells9426231
Quoted from UniProt’s FUNCTION annotation for P33527 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Plasma membrane
- Cell Junctionsadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Basolateral cell membrane
Expression by cell type
Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Choroid plexus epithelial cells183.8 nCPM
- Renal collecting duct intercalated cells104.3 nCPM
- Podocytes98.6 nCPM
- Papillary tip epithelial cells73.9 nCPM
- Renal collecting duct principal cells72.1 nCPM
- Renal connecting tubule cells67 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 1
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Multidrug resistance-associated protein 1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3533496 |
Other measurements 3
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Multidrug resistance-associated protein 1 | Drug transporters | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3533489 |
| Multidrug resistance-associated protein 1 | Drug transporters | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3533494 |
| Multidrug resistance-associated protein 1 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4191981 |