Multidrug and toxin extrusion protein 2
SLC and ABC transporters governing uptake and efflux — distinct from the monoamine transporters.
- Measurements
- 9
- Compounds
- 9
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Multidrug and toxin extrusion protein 2
Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney
Non-functional protein
Quoted from UniProt’s FUNCTION annotation for Q86VL8 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| SLC22A2 | 0.885 | 0.045 | 0.000 | 0.881 |
| SLC22A8 | 0.841 | 0.045 | 0.000 | 0.822 |
| SLC22A1 | 0.802 | 0.045 | 0.000 | 0.795 |
| SLC22A11 | 0.772 | 0.045 | 0.000 | 0.759 |
| SLC22A9 | 0.767 | 0.045 | 0.000 | 0.761 |
| SLCO1B3 | 0.764 | 0.000 | 0.000 | 0.764 |
| SLC22A6 | 0.737 | 0.045 | 0.000 | 0.712 |
| SLC22A7 | 0.730 | 0.045 | 0.000 | 0.709 |
| SLC29A4 | 0.722 | 0.000 | 0.000 | 0.722 |
| SLCO1B1 | 0.720 | 0.000 | 0.000 | 0.720 |
Where it sits in the cell
UniProt, curated Cell membrane · Apical cell membrane
Expression by cell type
Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Ependymal cells489.2 nCPM
- Proximal tubule cells298.8 nCPM
- Choroid plexus epithelial cells157.9 nCPM
- Epididymal efferent duct ciliated cells142.3 nCPM
- Epicardial cells113.7 nCPM
- Fallopian tube ciliated cells60.9 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- choroid plexus123 nTPM
- kidney61.3 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 9
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Multidrug and toxin extrusion protein 2 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187932 |
| Multidrug and toxin extrusion protein 2 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187932 |
| Multidrug and toxin extrusion protein 2 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187932 |
| Multidrug and toxin extrusion protein 2 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187932 |
| Multidrug and toxin extrusion protein 2 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187932 |
| Multidrug and toxin extrusion protein 2 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187932 |
| Multidrug and toxin extrusion protein 2 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187932 |
| Multidrug and toxin extrusion protein 2 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187932 |
| Multidrug and toxin extrusion protein 2 | Drug transporters | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187942 |