Multidrug and toxin extrusion protein 1
SLC and ABC transporters governing uptake and efflux — distinct from the monoamine transporters.
- Measurements
- 12
- Compounds
- 9
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Multidrug and toxin extrusion protein 1
Multidrug efflux pump that functions as a H(+)/organic cation antiporter16330770,17509534. Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively16330770,17495125,17509534,17582384,18305230,19158817,21128598,24961373. Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate16330770,17495125,17509534,17582384,18305230,19158817,21128598,24961373. May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable)
Quoted from UniProt’s FUNCTION annotation for Q96FL8 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| SLC22A2 | 0.902 | 0.145 | 0.000 | 0.887 |
| SLC22A1 | 0.860 | 0.045 | 0.000 | 0.855 |
| SLC22A8 | 0.817 | 0.045 | 0.000 | 0.802 |
| SLC22A9 | 0.765 | 0.045 | 0.000 | 0.759 |
| SLCO1B3 | 0.763 | 0.000 | 0.000 | 0.763 |
| SLCO1B1 | 0.762 | 0.000 | 0.000 | 0.760 |
| SLC22A11 | 0.756 | 0.045 | 0.000 | 0.750 |
| SLC22A6 | 0.752 | 0.045 | 0.000 | 0.733 |
| ABCG2 | 0.752 | 0.000 | 0.000 | 0.715 |
| SLC22A7 | 0.748 | 0.045 | 0.000 | 0.729 |
Where it sits in the cell
UniProt, curated Cell membrane · Apical cell membrane
Expression by cell type
Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Proximal tubule cells453.8 nCPM
- Early spermatids376.9 nCPM
- Late primary spermatocytes175.8 nCPM
- Epididymal efferent duct absorptive cells168.3 nCPM
- Myosatellite cells156.2 nCPM
- Adrenal cortex cells140.3 nCPM
- Myonuclei123.9 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- adrenal gland124.8 nTPM
- liver97 nTPM
- kidney93.6 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 12
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Multidrug and toxin extrusion protein 1 | Drug transporters | Vmax | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187935 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | Km | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187936 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | CL | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187937 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187931 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187931 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187931 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187931 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187931 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187931 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187931 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187931 |
| Multidrug and toxin extrusion protein 1 | Drug transporters | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6187941 |