Mitogen-activated protein kinase 15

Mitogen-activated protein kinase 15

Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner20733054,21847093,22948227,24618899,29021280. Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation22948227. Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling29021280. Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins24618899. Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion21847093. Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA20733054. Regulates DA transporter (DAT) activity and protein expression via activation of RhoA28842414. In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression26595526. Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP11875070,16484222,19166846,20638370. During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity21190936

Quoted from UniProt’s FUNCTION annotation for Q8TD08 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Where it sits in the cell

• Nucleoplasm
• Cytosol
• Vesiclesadditional
• Cell Junctionsadditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cytoplasm, cytoskeleton, cilium basal body · Cell junction, tight junction · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole · Cytoplasmic vesicle, autophagosome · Golgi apparatus · Nucleus · Cytoplasm · Cytoplasm, cytoskeleton, spindle

Expression by cell type

Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

• Ependymal cells134.2 nCPM
• Choroid plexus epithelial cells105.6 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

• choroid plexus70.7 nTPM
• fallopian tube36.1 nTPM