Mitogen-activated protein kinase 13
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Mitogen-activated protein kinase 13
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells
Quoted from UniProt’s FUNCTION annotation for O15264 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nucleoplasm
- Nucleoli
- Nucleoli rim
- Cytosol
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
Expression by cell type
Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Esophageal apical cells474.9 nCPM
- Late spermatids457.1 nCPM
- Breast lactating cells315.8 nCPM
- Esophageal suprabasal cells262.2 nCPM
- Late primary spermatocytes200.1 nCPM
- Enterocytes171.9 nCPM
- Esophageal basal cells159.7 nCPM
- Colonocytes139.1 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 13 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060132 |
| Mitogen-activated protein kinase 13 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060132 |
| Mitogen-activated protein kinase 13 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060132 |
| Mitogen-activated protein kinase 13 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060132 |