Metabotropic glutamate receptor 5
NMDA, AMPA, kainate and metabotropic receptors.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 1
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Metabotropic glutamate receptor 5
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity
Quoted from UniProt’s FUNCTION annotation for P41594 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 11 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Brain inhibitory neurons1,299 nCPM
- Oligodendrocyte progenitor cells1,160.3 nCPM
- Bergmann glia929.7 nCPM
- Brain excitatory neurons870.3 nCPM
- Retinal bipolar cells713.3 nCPM
- Other brain neurons430.4 nCPM
- Gonadotrophs304.4 nCPM
- Lactotrophs291.9 nCPM
- Early spermatids267.4 nCPM
- Endometrial ciliated cells230.1 nCPM
- Retinal amacrine cells220.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain13.9 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 1
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 | Glutamate receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL711712 |