Metabotropic glutamate receptor 1
NMDA, AMPA, kainate and metabotropic receptors.
- Measurements
- 2
- Compounds
- 1
- Binding constants
- 1
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Metabotropic glutamate receptor 1
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum24603153,28886343,7476890. May function in the light response in the retina (By similarity). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively24357660,27276689
Quoted from UniProt’s FUNCTION annotation for Q13255 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Vesicles
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Postsynaptic cell membrane · Cell projection, dendrite
Expression by cell type
Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Brain excitatory neurons529.4 nCPM
- Rod photoreceptor cells392.7 nCPM
- Brain inhibitory neurons328.5 nCPM
- Retinal ganglion cells131.3 nCPM
- Other brain neurons98.6 nCPM
- Retinal amacrine cells84.6 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain16 nTPM
- retina5.1 nTPM
II · Anatomy
Where the gene is transcribed
The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.
Brain
basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.
Measured but not drawn — this anatomogram has no outline for them: retina 5.1, midbrain 1.5, spinal cord 0.6.
Body
Square-root ramp · shared scale across both plates
Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of GRM1 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.
Brain · 9
- cerebellum16.0 nTPM
- retina5.1 nTPM
- cerebral cortex4.0 nTPM
- hippocampal formation2.6 nTPM
- hypothalamus1.8 nTPM
- amygdala1.6 nTPM
- basal ganglia1.6 nTPM
- midbrain1.5 nTPM
- spinal cord0.6 nTPM
Peripheral and autonomic · 3
- heart muscle2.6 nTPM
- kidney0.7 nTPM
- thyroid gland0.1 nTPM
Transcript is not protein. These are RNA levels for GRM1, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 1
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 | Glutamate receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL719076 |
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 | Glutamate receptors | EC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL822312 |