Maternal embryonic leucine zipper kinase
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Maternal embryonic leucine zipper kinase
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis
Quoted from UniProt’s FUNCTION annotation for Q14680 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 12 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Monocyte progenitors117.7 nCPM
- Sertoli cells117.6 nCPM
- Erythrocyte progenitors110.7 nCPM
- Extravillous trophoblasts81.6 nCPM
- Early primary spermatocytes76.6 nCPM
- Differentiating spermatogonia64.9 nCPM
- Migrating cytotrophoblasts47.7 nCPM
- Neutrophil progenitors44.3 nCPM
- Esophageal basal cells43 nCPM
- Respiratory deuterosomal cells41.5 nCPM
- Enteric transient amplifying cells41.1 nCPM
- Gastric progenitor cells39.7 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- lymphoid tissue19.6 nTPM
- bone marrow9.6 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Maternal embryonic leucine zipper kinase | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1052104 |
| Maternal embryonic leucine zipper kinase | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1052104 |
| Maternal embryonic leucine zipper kinase | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1052104 |
| Maternal embryonic leucine zipper kinase | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1052104 |