TargetEnzymes

MAP/microtubule affinity-regulating kinase 3

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements: 4
Compounds: 4
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

MARK3_HUMANMARK3Homo sapiens

MAP/microtubule affinity-regulating kinase 3

Serine/threonine-protein kinase16822840,16980613,23666762. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU23666762. Phosphorylates CDC25C on 'Ser-216'12941695. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus16980613. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol16822840. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS128087714. Phosphorylates PKP2 and KSR112941695

Quoted from UniProt’s FUNCTION annotation for P27448 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
KSR1	0.976	0.636	0.900	0.409
CDC25C	0.945	0.735	0.000	0.802
YWHAZ	0.928	0.860	0.000	0.501
YWHAB	0.926	0.804	0.500	0.295
YWHAG	0.888	0.790	0.000	0.480
MAP4	0.853	0.093	0.000	0.841
YWHAE	0.847	0.812	0.000	0.212
YWHAH	0.833	0.806	0.000	0.167
MARK2	0.804	0.781	0.000	0.066
F2R	0.782	0.042	0.000	0.782

Where it sits in the cell

UniProt, curated Cell membrane · Cell projection, dendrite · Cytoplasm

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Other measurements 4

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
MAP/microtubule affinity-regulating kinase 3	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1063734
MAP/microtubule affinity-regulating kinase 3	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1063734
MAP/microtubule affinity-regulating kinase 3	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1063734
MAP/microtubule affinity-regulating kinase 3	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1063734

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