MAP kinase-interacting serine/threonine-protein kinase 2
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
MAP kinase-interacting serine/threonine-protein kinase 2
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal
Quoted from UniProt’s FUNCTION annotation for Q9HBH9 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nuclear bodies
- Nucleoplasmadditional
- Cytosoladditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus, PML body · Cytoplasm
Expression by cell type
Single cell type RNA, the 5 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Esophageal apical cells726.9 nCPM
- Esophageal suprabasal cells320.3 nCPM
- Pancreatic acinar cells296.4 nCPM
- Thymic myoid cells282.8 nCPM
- Neutrophils272.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- skeletal muscle1,308.2 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060126 |
| MAP kinase-interacting serine/threonine-protein kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060126 |
| MAP kinase-interacting serine/threonine-protein kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060126 |
| MAP kinase-interacting serine/threonine-protein kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060126 |