MAP kinase-interacting serine/threonine-protein kinase 1
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
MAP kinase-interacting serine/threonine-protein kinase 1
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap
Quoted from UniProt’s FUNCTION annotation for Q9BUB5 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| MAPK1 | 0.999 | 0.981 | 0.900 | 0.558 |
| EIF4G1 | 0.990 | 0.374 | 0.000 | 0.984 |
| EIF4E | 0.965 | 0.357 | 0.000 | 0.947 |
| MAPK3 | 0.956 | 0.426 | 0.900 | 0.230 |
| MKNK2 | 0.945 | 0.443 | 0.900 | 0.074 |
| EIF4A2 | 0.928 | 0.000 | 0.000 | 0.928 |
| EIF4A1 | 0.927 | 0.000 | 0.000 | 0.927 |
| MAPK14 | 0.916 | 0.829 | 0.000 | 0.484 |
| EIF4E2 | 0.915 | 0.000 | 0.900 | 0.182 |
| EIF4G2 | 0.912 | 0.292 | 0.000 | 0.877 |
Where it sits in the cell
- Nucleoplasm
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Nucleus
Expression by cell type
Single cell type RNA, the 4 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Neutrophils590.9 nCPM
- Hofbauer cells367.7 nCPM
- Microglia365.3 nCPM
- Kupffer cells192.7 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- pancreas112.4 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063759 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063759 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063759 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063759 |