MAP kinase-activated protein kinase 5
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
MAP kinase-activated protein kinase 5
Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement
Quoted from UniProt’s FUNCTION annotation for Q8IW41 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| MAPK6 | 0.997 | 0.892 | 0.900 | 0.800 |
| HSPB1 | 0.995 | 0.739 | 0.900 | 0.841 |
| MAPK12 | 0.966 | 0.368 | 0.900 | 0.503 |
| MAPK14 | 0.956 | 0.429 | 0.900 | 0.265 |
| MAPK4 | 0.953 | 0.818 | 0.700 | 0.214 |
| MAPK11 | 0.953 | 0.368 | 0.900 | 0.310 |
| DNAJB1 | 0.947 | 0.000 | 0.900 | 0.493 |
| MAPK13 | 0.945 | 0.368 | 0.900 | 0.168 |
| HSPB2 | 0.862 | 0.298 | 0.000 | 0.812 |
| SEPTIN7 | 0.826 | 0.000 | 0.800 | 0.149 |
Where it sits in the cell
- Nucleoplasm
- Cytosoladditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Nucleus
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| MAP kinase-activated protein kinase 5 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061101 |
| MAP kinase-activated protein kinase 5 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061101 |
| MAP kinase-activated protein kinase 5 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061101 |
| MAP kinase-activated protein kinase 5 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061101 |