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PsychedeliaDokholyan Laboratory
TargetUnclassified

M1

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
176
Compounds
22
Binding constants
55
Median pX
8.39

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

ACM1_HUMANCHRM1Homo sapiens

Muscarinic acetylcholine receptor M1

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover

Quoted from UniProt’s FUNCTION annotation for P11229 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
GNAQ0.9630.0000.9000.647
GRM50.9500.0000.9000.389
LPAR60.9310.0000.9000.346
GNA110.9200.0000.9000.223
LPAR10.9160.0000.9000.187
KNG10.9140.0000.9000.179
GNG120.9110.0000.9000.138
CHRM30.9100.0000.9000.083
LPAR30.9080.0000.9000.119
CHRM20.9080.0000.9000.095

Where it sits in the cell

UniProt, curated Cell membrane · Postsynaptic cell membrane

Expression by cell type

Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Prostatic glandular cells52.2 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • brain48.4 nTPM
  • prostate27.8 nTPM
  • salivary gland27.1 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 48.4 nTPM, from CHRM1cerebellum — 0.1 nTPM, from CHRM1hippocampal formation — 26.3 nTPM, from CHRM1amygdala — 19.7 nTPM, from CHRM1hypothalamus — 3.0 nTPM, from CHRM1thalamus — no resolved target expressed herebasal ganglia — 39.9 nTPM, from CHRM1medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: midbrain 1.6, spinal cord 0.3, pituitary gland 0.1, retina 0.1.

Body

heart — 0.1 nTPM, from CHRM1smooth muscle — no resolved target expressed herelung — 2.4 nTPM, from CHRM1liver — no resolved target expressed herekidney — 0.2 nTPM, from CHRM1stomach — 1.3 nTPM, from CHRM1duodenum — 0.4 nTPM, from CHRM1small intestine — 0.6 nTPM, from CHRM1colon — 0.8 nTPM, from CHRM1adrenal gland — 3.1 nTPM, from CHRM1thyroid gland — 0.2 nTPM, from CHRM1pancreas — 0.6 nTPM, from CHRM1urinary bladder — no resolved target expressed hereskeletal muscle — no resolved target expressed herespleen — no resolved target expressed heresalivary gland — 27.1 nTPM, from CHRM1
048 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of CHRM1 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • cerebral cortex48.4 nTPM
  • basal ganglia39.9 nTPM
  • hippocampal formation26.3 nTPM
  • amygdala19.7 nTPM
  • hypothalamus3.0 nTPM
  • midbrain1.6 nTPM
  • spinal cord0.3 nTPM
  • cerebellum0.1 nTPM
  • pituitary gland0.1 nTPM
  • retina0.1 nTPM

Peripheral and autonomic · 11

  • salivary gland27.1 nTPM
  • adrenal gland3.1 nTPM
  • lung2.4 nTPM
  • stomach 11.3 nTPM
  • colon0.8 nTPM
  • small intestine0.6 nTPM
  • pancreas0.6 nTPM
  • duodenum0.4 nTPM
  • kidney0.2 nTPM
  • thyroid gland0.2 nTPM
  • heart muscle0.1 nTPM

Transcript is not protein. These are RNA levels for CHRM1, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

III · Ranking

Compounds by strongest binding constant

One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.

  1. 01Scopolamine9.73
  2. 023-Quinuclidinyl benzilate9.66
  3. 03Atropine9.59
  4. 04Arecoline8.39
  5. 05Muscarine7.57
  6. 06Ergotamine6.06
  7. 07Methysergide5.26

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 55

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
M1UnclassifiedKi0.1869.73RATPMID 2250662
M1UnclassifiedKi0.2209.66Bos taurusCHEMBL872660
M1UnclassifiedKi0.2609.59Rattus norvegicusCHEMBL745663
M1UnclassifiedKi0.3009.52Homo sapiensCHEMBL1013935
M1UnclassifiedKi0.3169.50RATPMID 2188581
M1UnclassifiedKi0.3669.44Homo sapiensCHEMBL1909170
M1UnclassifiedKi0.4109.39Bos taurusCHEMBL745466
M1UnclassifiedKi0.5309.28Rattus norvegicusCHEMBL745924
M1UnclassifiedKi1.108.96HUMANPMID 1346637
M1UnclassifiedKi2.008.70Homo sapiensCHEMBL745744
M1UnclassifiedKi4.108.39HUMANPMID 1704434
M1UnclassifiedKi27.007.57Rattus norvegicusCHEMBL746585
M1UnclassifiedKi27.007.57Rattus norvegicusCHEMBL745814
M1UnclassifiedKi29.007.54HUMANPMID 12747793
M1UnclassifiedKi8626.06HUMANPDSP
M1UnclassifiedKi5,4595.26HUMANPDSP
M1UnclassifiedKi5,9505.23RATPMID 1310135
M1UnclassifiedKi29,0004.54Homo sapiensCHEMBL744768
M1UnclassifiedKi86,0004.07Rattus norvegicusCHEMBL969250
M1UnclassifiedKi86,0004.07Rattus norvegicusCHEMBL1054450
M1UnclassifiedKi88,0004.06Rattus norvegicusCHEMBL1111846
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL747398
M1UnclassifiedKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL714427
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2380035
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2215470
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4373108
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2215474
M1UnclassifiedKi— no normalized value— value does not convert to pXMus musculusCHEMBL748968
M1UnclassifiedKi— no normalized value— value does not convert to pXMus musculusCHEMBL748051
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL747393
M1UnclassifiedKi— no normalized value— value does not convert to pXBos taurusCHEMBL883687
M1UnclassifiedKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL790102
M1UnclassifiedKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL744273
M1UnclassifiedKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1218689
M1UnclassifiedKi— no normalized value— value does not convert to pXBos taurusCHEMBL747248
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2317408
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedKd— no normalized value— value does not convert to pXRattus norvegicusCHEMBL746582
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL744767
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL923035
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL923035
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedKd— no normalized value— value does not convert to pXRattus norvegicusCHEMBL746582
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2395815
M1UnclassifiedKd— no normalized value— value does not convert to pXHomo sapiensCHEMBL5544642
M1UnclassifiedKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL2319076
M1UnclassifiedKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL2319076
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL744920
M1UnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL744920
M1UnclassifiedKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL748259
M1UnclassifiedKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL872655

Functional readouts 71

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
M1UnclassifiedIC501.528.82Homo sapiensCHEMBL1909170
M1UnclassifiedIC501,1005.96Rattus norvegicusCHEMBL752317
M1UnclassifiedIC501,7385.76Rattus norvegicusCHEMBL857187
M1UnclassifiedIC501,7405.76Rattus norvegicusCHEMBL752316
M1UnclassifiedEC503,2005.49Homo sapiensCHEMBL744231
M1UnclassifiedIC505,6805.25Rattus norvegicusCHEMBL752316
M1UnclassifiedIC5011,9204.92Rattus norvegicusCHEMBL748851
M1UnclassifiedIC5065,0004.19Homo sapiensCHEMBL744321
M1UnclassifiedEC50— no normalized value— value does not convert to pXMus musculusCHEMBL746423
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL744234
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL744235
M1UnclassifiedEC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL745750
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL752914
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL751533
M1UnclassifiedEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL748279
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL748852
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL751537
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL751538
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL881931
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747492
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747493
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL745687
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL969250
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1054450
M1UnclassifiedIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1111846
M1UnclassifiedEC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL748216
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909170
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291763
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291759
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291759
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291759
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291759
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291759
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291761
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291761
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291761
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291761
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291761
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291761
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613997
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613997
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613997
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613997
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613997
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613991
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613991
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613991
M1UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1613991
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3383649
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3384240
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3385563
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291920
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291920
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291760
M1UnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291760
M1UnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5544643

Other measurements 50

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

TargetClassTypeValue (nM)pXOrganismAssay
M1UnclassifiedActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL5581349
M1UnclassifiedInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL744325
M1UnclassifiedInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL744325
M1UnclassifiedInhibition— no normalized value— value does not convert to pXMus musculusCHEMBL748964
M1UnclassifiedInhibition— no normalized value— value does not convert to pXMus musculusCHEMBL748965
M1UnclassifiedSmax— no normalized value— value does not convert to pXMus musculusCHEMBL748052
M1UnclassifiedMax PI— no normalized value— value does not convert to pXHomo sapiensCHEMBL744060
M1UnclassifiedMax PI— no normalized value— value does not convert to pXHomo sapiensCHEMBL744061
M1UnclassifiedMax— no normalized value— value does not convert to pXHomo sapiensCHEMBL773336
M1UnclassifiedInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747499
M1UnclassifiedInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL744326
M1UnclassifiedInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747494
M1UnclassifiedInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747494
M1UnclassifiedInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747494
M1UnclassifiedpD2— no normalized value— value does not convert to pXRattus norvegicusCHEMBL800066
M1UnclassifiedpD2— no normalized value— value does not convert to pXRattus norvegicusCHEMBL800066
M1UnclassifiedpD2— no normalized value— value does not convert to pXRattus norvegicusCHEMBL798083
M1UnclassifiedpD2— no normalized value— value does not convert to pXRattus norvegicusCHEMBL798083
M1UnclassifiedRatio— no normalized value— value does not convert to pXRattus norvegicusCHEMBL745822
M1UnclassifiedRatio— no normalized value— value does not convert to pXRattus norvegicusCHEMBL745822
M1UnclassifiedK app— no normalized value— value does not convert to pXRattus norvegicusCHEMBL846207
M1UnclassifiedED50— no normalized value— value does not convert to pXHomo sapiensCHEMBL747252
M1UnclassifiedED50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL749923
M1UnclassifiedInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747496
M1UnclassifiedInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747500
M1UnclassifiedInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL747497
M1UnclassifiedInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL744327
M1UnclassifiedpD2— no normalized value— value does not convert to pXRattus norvegicusCHEMBL745632
M1UnclassifiedEfficacy— no normalized value— value does not convert to pXRattus norvegicusCHEMBL748258
M1UnclassifiedpD2— no normalized value— value does not convert to pXRattus norvegicusCHEMBL748401
M1UnclassifiedEfficacy— no normalized value— value does not convert to pXRattus norvegicusCHEMBL748256
M1UnclassifiedRatio— no normalized value— value does not convert to pXHomo sapiensCHEMBL850283
M1UnclassifiedInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4687677
M1UnclassifiedRatio— no normalized value— value does not convert to pXHomo sapiensCHEMBL851333
M1UnclassifiedActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL2166006
M1UnclassifiedRatio— no normalized value— value does not convert to pXRattus norvegicusCHEMBL4676761
M1UnclassifiedKb— no normalized value— value does not convert to pXHomo sapiensCHEMBL714431
M1UnclassifiedK 0.5— no normalized value— value does not convert to pXMus musculusCHEMBL748966
M1UnclassifiedActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL1016624
M1UnclassifiedKb— no normalized value— value does not convert to pXHomo sapiensCHEMBL748054
M1UnclassifiedInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL5547460
M1UnclassifiedImax— no normalized value— value does not convert to pXHomo sapiensCHEMBL2317405
M1UnclassifiedImax— no normalized value— value does not convert to pXHomo sapiensCHEMBL3383650
M1UnclassifiedImax— no normalized value— value does not convert to pXHomo sapiensCHEMBL3385556
M1UnclassifiedImax— no normalized value— value does not convert to pXHomo sapiensCHEMBL3385564
M1UnclassifiedActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL5337071
M1UnclassifiedActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL5337071
M1UnclassifiedImax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4373109
M1UnclassifiedKapp— no normalized value— value does not convert to pXRattus norvegicusCHEMBL4676762
M1UnclassifiedKapp— no normalized value— value does not convert to pXRattus norvegicusCHEMBL4676763
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