Skip to content
PsychedeliaDokholyan Laboratory
TargetEnzymes

Lysine-specific demethylase 4E

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
27
Compounds
15
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

KDM4E_HUMANKDM4EHomo sapiens

Lysine-specific demethylase 4E

Histone demethylase that demethylates trimethylated 'Lys-9' of histone H3 into monomethylated form, thereby playing a central role in histone code21914792,23451023. Also demethylates trimethylated 'Lys-56' of histone H3 (H3K9me3) to generate the monomethylated state (H3K56me1)23451023

Quoted from UniProt’s FUNCTION annotation for B2RXH2 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
JMJD1C0.6970.0000.0000.697
KDM2A0.6450.0660.0000.636
PHF80.6260.0660.0000.616
KDM3A0.6140.0000.0000.614
KDM6B0.5990.0700.0000.584
KDM1A0.5590.0810.0000.508
ADH50.5550.0000.0000.555
KDM7A0.5400.0660.0000.528
KDM3B0.5190.0000.0000.519
KDM1B0.4970.0690.0000.462

Where it sits in the cell

UniProt, curated Nucleus

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — no resolved target expressed herecerebellum — no resolved target expressed herehippocampal formation — no resolved target expressed hereamygdala — no resolved target expressed herehypothalamus — no resolved target expressed herethalamus — no resolved target expressed herebasal ganglia — no resolved target expressed heremedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 0.1.

Body

heart — no resolved target expressed heresmooth muscle — no resolved target expressed herelung — no resolved target expressed hereliver — no resolved target expressed herekidney — no resolved target expressed herestomach — no resolved target expressed hereduodenum — no resolved target expressed heresmall intestine — no resolved target expressed herecolon — no resolved target expressed hereadrenal gland — no resolved target expressed herethyroid gland — 0.1 nTPM, from KDM4Epancreas — no resolved target expressed hereurinary bladder — 0.1 nTPM, from KDM4Eskeletal muscle — no resolved target expressed herespleen — 0.1 nTPM, from KDM4Esalivary gland — 0.2 nTPM, from KDM4E
01 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of KDM4E transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 1

  • pituitary gland0.1 nTPM

Peripheral and autonomic · 4

  • salivary gland0.2 nTPM
  • thyroid gland0.1 nTPM
  • urinary bladder0.1 nTPM
  • spleen0.1 nTPM

Transcript is not protein. These are RNA levels for KDM4E, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 27

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
Lysine-specific demethylase 4EEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613914
← All targets