Leukotriene C4 synthase
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 14
- Compounds
- 7
- Binding constants
- 7
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Leukotriene C4 synthase
Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity23409838,27365393,27791009,7937884,9153254. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions27791009
Quoted from UniProt’s FUNCTION annotation for Q16873 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nucleoplasm
- Endoplasmic reticulumadditional
- Cytosoladditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus outer membrane · Endoplasmic reticulum membrane · Nucleus membrane
Expression by cell type
Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Mast cells284.8 nCPM
- Microglia165.2 nCPM
- Fallopian secretory cells77.4 nCPM
- Hofbauer cells70.9 nCPM
- Megakaryocytes61.8 nCPM
- Hepatic stellate cells51.6 nCPM
- Lymphatic endothelial cells50.6 nCPM
- Macrophages43.8 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 7
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Leukotriene C4 synthase | Enzymes | Ki | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | Ki | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | Ki | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | Ki | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | Ki | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | Ki | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | Ki | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
Functional readouts 7
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Leukotriene C4 synthase | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |
| Leukotriene C4 synthase | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Cavia porcellus | CHEMBL1909163 |