Homeodomain-interacting protein kinase 3
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 6
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Homeodomain-interacting protein kinase 3
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)
Quoted from UniProt’s FUNCTION annotation for Q9H422 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Cytosol
- Nuclear bodiesadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Nucleus
Expression by cell type
Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Neutrophils1,249.2 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 6
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Homeodomain-interacting protein kinase 3 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061964 |
| Homeodomain-interacting protein kinase 3 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061964 |
| Homeodomain-interacting protein kinase 3 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061964 |
| Homeodomain-interacting protein kinase 3 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061964 |
| Homeodomain-interacting protein kinase 3 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4151467 |
| Homeodomain-interacting protein kinase 3 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4344405 |