High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP18757755,21483814,9624146. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart25799991. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity)

Quoted from UniProt’s FUNCTION annotation for O76083 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Where it sits in the cell

• Cytosol
• Nucleoplasmadditional
• Plasma membraneadditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell projection, ruffle membrane · Cytoplasm, perinuclear region · Golgi apparatus · Endoplasmic reticulum · Cell membrane, sarcolemma · Cytoplasm

Expression by cell type

Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

• Enterocytes513.9 nCPM
• Prostatic glandular cells323.4 nCPM
• Oocytes216.4 nCPM
• Retinal horizontal cells202.3 nCPM
• Loop of henle epithelial cells197.6 nCPM
• Somatotrophs191.4 nCPM
• Renal connecting tubule cells184.7 nCPM
• Renal collecting duct principal cells165.5 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

• intestine69.9 nTPM