Glycogen synthase kinase-3
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 6
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
No single gene answers to Glycogen synthase kinase-3. Names like this one are families or unsubtyped preparations — a measurement made against whatever receptors a tissue carried, before or without resolving which subtype bound the compound. A family has no one accession, and picking a member to stand for it would invent a precision the assay never had: asked for “Muscarinic acetylcholine receptor” UniProt returns CHRM1, and that answer is wrong.
Resolver said no gene lists this target name as a synonym — recorded by tools/fetch_expression.py, not written here.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 6
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 | Enzymes | IC50 | 19,000 | 4.72 | Sus scrofa | CHEMBL2187126 |
| Glycogen synthase kinase-3 | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Sus scrofa | CHEMBL2320287 |
| Glycogen synthase kinase-3 | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3381516 |
| Glycogen synthase kinase-3 | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3870425 |
| Glycogen synthase kinase-3 | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Sus scrofa | CHEMBL3875855 |
| Glycogen synthase kinase-3 | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Sus scrofa | CHEMBL4022016 |