Glycine receptor subunit alpha-1
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 5
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Glycine receptor subunit alpha-1
Subunit of heteromeric glycine-gated chloride channels14551753,23994010,25730860,37821459. Plays an important role in the down-regulation of neuronal excitability8298642,9009272. Contributes to the generation of inhibitory postsynaptic currents25445488. Channel activity is potentiated by ethanol25973519. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity)
Quoted from UniProt’s FUNCTION annotation for P23415 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Vesicles
- Plasma membrane
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Postsynaptic cell membrane · Synapse · Perikaryon · Cell projection, dendrite · Cell membrane
Expression by cell type
Single cell type RNA, the 11 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Retinal bipolar cells81.9 nCPM
- Adrenal medulla cells42.5 nCPM
- Cardiomyocytes39.9 nCPM
- Retinal amacrine cells30.5 nCPM
- Hepatic stellate cells25.8 nCPM
- Retinal ganglion cells23.2 nCPM
- Myonuclei21.4 nCPM
- Adipocytes19.4 nCPM
- Other brain neurons18.5 nCPM
- Rod photoreceptor cells16.7 nCPM
- Epicardial cells15.9 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- retina2.3 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Glycine receptor subunit alpha-1 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3423809 |
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Glycine receptor subunit alpha-1 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3423808 |
| Glycine receptor subunit alpha-1 | Other named receptors | %max | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3423810 |
| Glycine receptor subunit alpha-1 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1107109 |
| Glycine receptor subunit alpha-1 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1113523 |