Glutamate NMDA receptor; GRIN1/GRIN2A
NMDA, AMPA, kainate and metabotropic receptors.
- Measurements
- 20
- Compounds
- 4
- Binding constants
- 2
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
No single gene answers to Glutamate NMDA receptor; GRIN1/GRIN2A. Names like this one are families or unsubtyped preparations — a measurement made against whatever receptors a tissue carried, before or without resolving which subtype bound the compound. A family has no one accession, and picking a member to stand for it would invent a precision the assay never had: asked for “Muscarinic acetylcholine receptor” UniProt returns CHRM1, and that answer is wrong.
Resolver said no gene lists this target name as a synonym — recorded by tools/fetch_expression.py, not written here.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 2
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | Ki | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL4687806 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4687811 |
Functional readouts 12
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1764160 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1764160 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3242673 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3242673 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL5166010 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6117156 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6118020 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6118020 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6085756 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6085758 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6117147 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1105653 |
Other measurements 6
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1764160 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1764160 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5166038 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5166039 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1105657 |
| Glutamate NMDA receptor; GRIN1/GRIN2A | Glutamate receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1105660 |