Glucagon-like peptide 1 receptor
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 8
- Compounds
- 3
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Glucagon-like peptide 1 receptor
G protein-coupled receptor for glucagon-like peptide 1 (GLP-1)19861722,26308095,27196125,28514449,7517895,8216285,8405712. Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels19861722,26308095,27196125,28514449,7517895,8216285,8405712. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity)
Quoted from UniProt’s FUNCTION annotation for P43220 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nuclear bodies
- Plasma membrane
- Golgi apparatusadditional
- Centrosomeadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Tuft cells46.1 nCPM
- Pancreatic islet cells23.3 nCPM
- Lacrimal acinar cells19 nCPM
- Pancreatic acinar cells15.5 nCPM
- Other brain neurons10.8 nCPM
- Neuroendocrine cells8 nCPM
- Proximal tubule cells5.7 nCPM
- Salivary acinar cells4.8 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- pancreas8.6 nTPM
- heart muscle2.6 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor | Other named receptors | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2114931 |
Other measurements 7
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor | Other named receptors | %Max (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209829 |
| Glucagon-like peptide 1 receptor | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209829 |
| Glucagon-like peptide 1 receptor | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209829 |
| Glucagon-like peptide 1 receptor | Other named receptors | %Max (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209829 |
| Glucagon-like peptide 1 receptor | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209829 |
| Glucagon-like peptide 1 receptor | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209830 |
| Glucagon-like peptide 1 receptor | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209831 |