G-protein coupled receptor 55
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 17
- Compounds
- 6
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
G protein-coupled receptor 55
G protein-coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways36142844,36523570,37544935. Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation36142844. In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation37544935
Quoted from UniProt’s FUNCTION annotation for Q9Y2T6 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Sertoli cells56 nCPM
- Tuft cells46.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- testis4.4 nTPM
- lymphoid tissue4.2 nTPM
- brain3.5 nTPM
II · Anatomy
Where the gene is transcribed
The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.
Brain
basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.
Measured but not drawn — this anatomogram has no outline for them: pituitary gland 0.4, midbrain 0.1, spinal cord 0.1.
Body
Square-root ramp · shared scale across both plates
Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of GPR55 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.
Brain · 8
- basal ganglia3.5 nTPM
- cerebral cortex0.6 nTPM
- pituitary gland0.4 nTPM
- hippocampal formation0.3 nTPM
- hypothalamus0.3 nTPM
- amygdala0.2 nTPM
- midbrain0.1 nTPM
- spinal cord0.1 nTPM
Peripheral and autonomic · 12
- spleen3.9 nTPM
- small intestine2.1 nTPM
- duodenum1.2 nTPM
- salivary gland0.9 nTPM
- colon0.8 nTPM
- urinary bladder0.8 nTPM
- stomach 10.7 nTPM
- lung0.4 nTPM
- heart muscle0.1 nTPM
- smooth muscle0.1 nTPM
- liver0.1 nTPM
- thyroid gland0.1 nTPM
Transcript is not protein. These are RNA levels for GPR55, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 10
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| G-protein coupled receptor 55 | Other named receptors | IC50 | 445 | 6.35 | Homo sapiens | CHEMBL6080640 |
| G-protein coupled receptor 55 | Other named receptors | EC50 | 445 | 6.35 | Homo sapiens | CHEMBL1117885 |
| G-protein coupled receptor 55 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3222510 |
| G-protein coupled receptor 55 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4731304 |
| G-protein coupled receptor 55 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3222504 |
| G-protein coupled receptor 55 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096644 |
| G-protein coupled receptor 55 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2339469 |
| G-protein coupled receptor 55 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096610 |
| G-protein coupled receptor 55 | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2388878 |
| G-protein coupled receptor 55 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3222510 |
Other measurements 7
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| G-protein coupled receptor 55 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4731305 |
| G-protein coupled receptor 55 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2388863 |
| G-protein coupled receptor 55 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2388863 |
| G-protein coupled receptor 55 | Other named receptors | Efficacy | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096646 |
| G-protein coupled receptor 55 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096649 |
| G-protein coupled receptor 55 | Other named receptors | Kb | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2339471 |
| G-protein coupled receptor 55 | Other named receptors | Efficacy | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096615 |