Endonuclease 8-like 2
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 2
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Endonuclease 8-like 2
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Quoted from UniProt’s FUNCTION annotation for Q969S2 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nucleoplasm
- Vesiclesadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus
Expression by cell type
Single cell type RNA, the 12 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Other brain neurons17.7 nCPM
- Brain excitatory neurons10.8 nCPM
- Brain inhibitory neurons10.7 nCPM
- Oligodendrocyte progenitor cells9 nCPM
- Choroid plexus epithelial cells7.9 nCPM
- Microglia7.8 nCPM
- Ependymal cells7.4 nCPM
- Renal collecting duct principal cells7.4 nCPM
- Astrocytes7 nCPM
- Proximal tubule cells6.7 nCPM
- Oligodendrocytes6.6 nCPM
- Papillary tip epithelial cells5.7 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 2
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Endonuclease 8-like 2 | Enzymes | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5665448 |
| Endonuclease 8-like 2 | Enzymes | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5665448 |