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PsychedeliaDokholyan Laboratory
TargetEnzymes

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
6
Compounds
1
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

DYRK4_HUMANDYRK4Homo sapiens

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Possible non-essential role in spermiogenesis

Quoted from UniProt’s FUNCTION annotation for Q9NR20 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
DCAF70.8560.4570.0000.699
SLC13A50.5860.0000.0000.586
NRIP20.4350.0000.0000.435

Where it sits in the cell

  • Vesicles

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cytoplasm · Nucleus

Expression by cell type

Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Late spermatids446.7 nCPM
  • Early spermatids338.6 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • testis34.3 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 3.0 nTPM, from DYRK4cerebellum — 1.8 nTPM, from DYRK4hippocampal formation — 2.7 nTPM, from DYRK4amygdala — 2.6 nTPM, from DYRK4hypothalamus — 2.8 nTPM, from DYRK4thalamus — no resolved target expressed herebasal ganglia — 2.4 nTPM, from DYRK4medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 7.1, spinal cord 3.9, pituitary gland 3.5, midbrain 3.0.

Body

heart — 4.4 nTPM, from DYRK4smooth muscle — 4.8 nTPM, from DYRK4lung — 4.4 nTPM, from DYRK4liver — 3.9 nTPM, from DYRK4kidney — 3.3 nTPM, from DYRK4stomach — 3.0 nTPM, from DYRK4duodenum — 4.3 nTPM, from DYRK4small intestine — 3.7 nTPM, from DYRK4colon — 5.0 nTPM, from DYRK4adrenal gland — 4.0 nTPM, from DYRK4thyroid gland — 8.5 nTPM, from DYRK4pancreas — 2.9 nTPM, from DYRK4urinary bladder — 4.4 nTPM, from DYRK4skeletal muscle — 2.1 nTPM, from DYRK4spleen — 5.8 nTPM, from DYRK4salivary gland — 3.5 nTPM, from DYRK4
09 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of DYRK4 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • retina7.1 nTPM
  • spinal cord3.9 nTPM
  • pituitary gland3.5 nTPM
  • cerebral cortex3.0 nTPM
  • midbrain3.0 nTPM
  • hypothalamus2.8 nTPM
  • hippocampal formation2.7 nTPM
  • amygdala2.6 nTPM
  • basal ganglia2.4 nTPM
  • cerebellum1.8 nTPM

Peripheral and autonomic · 16

  • thyroid gland8.5 nTPM
  • spleen5.8 nTPM
  • colon5.0 nTPM
  • smooth muscle4.8 nTPM
  • heart muscle4.4 nTPM
  • lung4.4 nTPM
  • urinary bladder4.4 nTPM
  • duodenum4.3 nTPM
  • adrenal gland4.0 nTPM
  • liver3.9 nTPM
  • small intestine3.7 nTPM
  • salivary gland3.5 nTPM
  • kidney3.3 nTPM
  • stomach 13.0 nTPM
  • pancreas2.9 nTPM
  • skeletal muscle2.1 nTPM

Transcript is not protein. These are RNA levels for DYRK4, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 6

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Dual specificity tyrosine-phosphorylation-regulated kinase 4EnzymesIC509,5005.02Homo sapiensCHEMBL2187130
Dual specificity tyrosine-phosphorylation-regulated kinase 4EnzymesIC509,5005.02Homo sapiensCHEMBL5235548
Dual specificity tyrosine-phosphorylation-regulated kinase 4EnzymesIC5074,0004.13Homo sapiensCHEMBL3424977
Dual specificity tyrosine-phosphorylation-regulated kinase 4EnzymesIC5080,0004.10Homo sapiensCHEMBL5254670
Dual specificity tyrosine-phosphorylation-regulated kinase 4EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4008942
Dual specificity tyrosine-phosphorylation-regulated kinase 4EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5251373
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