Deoxycytidine kinase
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 2
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Deoxycytidine kinase
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine12808445,18377927,19159229,1996353,20614893,20637175. Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents12808445
Quoted from UniProt’s FUNCTION annotation for P27707 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nucleoplasm
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus
Expression by cell type
Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- pDCs148.8 nCPM
- Monocyte progenitors94.4 nCPM
- Kupffer cells85.1 nCPM
- Erythrocyte progenitors82.3 nCPM
- Platelets79.2 nCPM
- Early primary spermatocytes66.3 nCPM
- B-cells66.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- lymphoid tissue98.5 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 2
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Deoxycytidine kinase | Enzymes | Activity | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL663655 |
| Deoxycytidine kinase | Enzymes | Activity | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL663655 |