Cytochrome P450 2J2
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 11
- Compounds
- 3
- Binding constants
- 2
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Cytochrome P450 2J2
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system19965576,8631948. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase)19965576,8631948. Catalyzes the epoxidation of double bonds of PUFA19965576,8631948. Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools8631948. In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent19737933. Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone19923256. Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole23959307. Catalyzes the sulfoxidation of fenbedazole19923256
Quoted from UniProt’s FUNCTION annotation for P51589 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| EPHX2 | 0.981 | 0.068 | 0.906 | 0.785 |
| CYP4F3 | 0.970 | 0.092 | 0.905 | 0.586 |
| CYP4A11 | 0.954 | 0.091 | 0.910 | 0.327 |
| CYP4F2 | 0.951 | 0.092 | 0.905 | 0.314 |
| CYP3A4 | 0.951 | 0.076 | 0.908 | 0.318 |
| CYP4A22 | 0.948 | 0.091 | 0.910 | 0.237 |
| CYP4F8 | 0.945 | 0.092 | 0.905 | 0.235 |
| CYP2E1 | 0.944 | 0.071 | 0.912 | 0.313 |
| ALOX5 | 0.937 | 0.065 | 0.900 | 0.368 |
| CYP1A2 | 0.934 | 0.000 | 0.912 | 0.174 |
Where it sits in the cell
UniProt, curated Endoplasmic reticulum membrane · Microsome membrane
Expression by cell type
Single cell type RNA, the 11 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Syncytiotrophoblasts311.7 nCPM
- Cardiomyocytes306.1 nCPM
- Esophageal apical cells161.4 nCPM
- Enterocytes149.6 nCPM
- Bergmann glia146 nCPM
- Cytotrophoblasts134.8 nCPM
- Migrating cytotrophoblasts117.6 nCPM
- Respiratory secretory cells96.6 nCPM
- Myonuclei95.6 nCPM
- Oligodendrocytes80.2 nCPM
- Hepatocytes69 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- liver136.7 nTPM
- heart muscle83.9 nTPM
- intestine78.5 nTPM
II · Anatomy
Where the gene is transcribed
The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.
Brain
basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.
Measured but not drawn — this anatomogram has no outline for them: spinal cord 18.8, midbrain 15.5, retina 3.2, pituitary gland 0.8.
Body
Square-root ramp · shared scale across both plates
Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of CYP2J2 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.
Brain · 10
- basal ganglia20.7 nTPM
- spinal cord18.8 nTPM
- midbrain15.5 nTPM
- amygdala13.3 nTPM
- cerebral cortex13.1 nTPM
- hypothalamus12.0 nTPM
- hippocampal formation11.7 nTPM
- cerebellum7.8 nTPM
- retina3.2 nTPM
- pituitary gland0.8 nTPM
Peripheral and autonomic · 16
- liver136.7 nTPM
- heart muscle83.9 nTPM
- small intestine78.5 nTPM
- duodenum32.1 nTPM
- skeletal muscle23.7 nTPM
- colon17.9 nTPM
- salivary gland14.4 nTPM
- urinary bladder6.2 nTPM
- stomach 14.4 nTPM
- kidney2.8 nTPM
- pancreas2.1 nTPM
- smooth muscle1.7 nTPM
- lung1.3 nTPM
- adrenal gland0.4 nTPM
- thyroid gland0.1 nTPM
- spleen0.1 nTPM
Transcript is not protein. These are RNA levels for CYP2J2, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 2
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Cytochrome P450 2J2 | Enzymes | Kd | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624357 |
| Cytochrome P450 2J2 | Enzymes | Kd | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624353 |
Functional readouts 2
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Cytochrome P450 2J2 | Enzymes | IC50 | 19,000 | 4.72 | Homo sapiens | CHEMBL5096666 |
| Cytochrome P450 2J2 | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3541093 |
Other measurements 7
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Cytochrome P450 2J2 | Enzymes | Drug metabolism | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624336 |
| Cytochrome P450 2J2 | Enzymes | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624342 |
| Cytochrome P450 2J2 | Enzymes | Drug metabolism | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624350 |
| Cytochrome P450 2J2 | Enzymes | FC | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624361 |
| Cytochrome P450 2J2 | Enzymes | Drug metabolism | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624344 |
| Cytochrome P450 2J2 | Enzymes | Drug metabolism | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624326 |
| Cytochrome P450 2J2 | Enzymes | Drug metabolism | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5624331 |