Cyclin-dependent kinase-like 5
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Cyclin-dependent kinase-like 5
Mediates phosphorylation of MECP215917271,16935860. May regulate ciliogenesis29420175
Quoted from UniProt’s FUNCTION annotation for O76039 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| MECP2 | 0.975 | 0.292 | 0.000 | 0.963 |
| PCDH19 | 0.900 | 0.000 | 0.000 | 0.892 |
| FOXG1 | 0.866 | 0.000 | 0.000 | 0.866 |
| STXBP1 | 0.865 | 0.000 | 0.000 | 0.865 |
| SCN1A | 0.861 | 0.000 | 0.000 | 0.853 |
| NTNG1 | 0.847 | 0.000 | 0.000 | 0.844 |
| KCNQ2 | 0.844 | 0.000 | 0.000 | 0.837 |
| PCDH10 | 0.834 | 0.000 | 0.000 | 0.830 |
| SCN2A | 0.821 | 0.000 | 0.000 | 0.813 |
| SLC25A22 | 0.819 | 0.000 | 0.000 | 0.819 |
Where it sits in the cell
- Nucleoplasm
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus · Cytoplasm, cytoskeleton, cilium basal body · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Expression by cell type
Single cell type RNA, the 5 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Urothelial cells329.5 nCPM
- Alveolar cells type 1229.4 nCPM
- Neutrophils228 nCPM
- Cone photoreceptor cells223.6 nCPM
- Retinal horizontal cells220.4 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain12.8 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 1
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Cyclin-dependent kinase-like 5 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4151446 |