Citron Rho-interacting kinase
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Citron Rho-interacting kinase
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2
Quoted from UniProt’s FUNCTION annotation for O14578 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Cytosol
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm
Expression by cell type
Single cell type RNA, the 12 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Monocyte progenitors203 nCPM
- Brain inhibitory neurons190.2 nCPM
- Erythrocyte progenitors140.6 nCPM
- Ependymal cells132.8 nCPM
- Oligodendrocyte progenitor cells123.9 nCPM
- Brain excitatory neurons122 nCPM
- Distal convoluted tubule cells120.1 nCPM
- Megakaryocyte progenitors114.7 nCPM
- Transitional alveolar cells109.5 nCPM
- Cone photoreceptor cells105.6 nCPM
- Other brain neurons103.7 nCPM
- Neutrophil progenitors102.8 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain13.4 nTPM
- lymphoid tissue6.3 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 1
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Citron Rho-interacting kinase | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4151447 |