TargetEnzymes

Casein kinase I isoform epsilon

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements: 3
Compounds: 1
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

KC1E_HUMANCSNK1EHomo sapiens

Casein kinase I isoform epsilon

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling12556519,23413191. Phosphorylates DVL112556519. Phosphorylates DVL223413191. Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock16790549. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation15917222,16790549. Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation15070676

Quoted from UniProt’s FUNCTION annotation for P49674 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
PER2	0.999	0.890	0.900	0.983
CRY1	0.999	0.968	0.800	0.938
ARNTL	0.997	0.696	0.900	0.927
CRY2	0.997	0.757	0.800	0.960
PER1	0.996	0.897	0.900	0.672
PER3	0.994	0.551	0.900	0.880
CLOCK	0.994	0.558	0.900	0.887
AXIN1	0.993	0.617	0.900	0.844
GSK3B	0.989	0.086	0.900	0.889
CSNK1D	0.989	0.831	0.900	0.421

Where it sits in the cell

Nucleoplasm
Cytosol

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cytoplasm · Nucleus

Expression by cell type

Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

Bergmann glia117.2 nCPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 1

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Casein kinase I isoform epsilon	Enzymes	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5251364

Other measurements 2

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Casein kinase I isoform epsilon	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4151453
Casein kinase I isoform epsilon	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4344397

← All targets