Casein kinase I isoform delta
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 7
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Casein kinase I isoform delta
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate
Quoted from UniProt’s FUNCTION annotation for P48730 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Plasma membrane
- Cytosol
- Actin filamentsadditional
- Primary ciliumadditional
- Principal pieceadditional
- End pieceadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Nucleus · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · Cytoplasm, perinuclear region · Cell membrane · Cytoplasm, cytoskeleton, spindle · Golgi apparatus
Expression by cell type
Single cell type RNA, the 3 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Late spermatids1,358.7 nCPM
- Neutrophils605 nCPM
- Early spermatids371.3 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Casein kinase I isoform delta | Enzymes | IC50 | 1,500 | 5.82 | Homo sapiens | CHEMBL1061194 |
Other measurements 6
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Casein kinase I isoform delta | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1062001 |
| Casein kinase I isoform delta | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1062001 |
| Casein kinase I isoform delta | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1062001 |
| Casein kinase I isoform delta | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1062001 |
| Casein kinase I isoform delta | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4151452 |
| Casein kinase I isoform delta | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4344396 |