Casein kinase I isoform alpha
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 2
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Casein kinase I isoform alpha
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates11955436,1409656,18305108,23902688. It can phosphorylate a large number of proteins11955436,1409656,18305108,23902688. Participates in Wnt signaling11955436. Phosphorylates CTNNB1 at 'Ser-45'11955436. May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis1409656. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration23902688. Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor22017875,22017877. Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity)
Quoted from UniProt’s FUNCTION annotation for P48729 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Cytosol
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · Chromosome, centromere, kinetochore · Nucleus speckle · Cytoplasm, cytoskeleton, cilium basal body · Cytoplasm, cytoskeleton, spindle
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 2
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Casein kinase I isoform alpha | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4151451 |
| Casein kinase I isoform alpha | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4344395 |