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PsychedeliaDokholyan Laboratory
TargetEnzymes

Carbonic anhydrase 2

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
14
Compounds
7
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

CAH2_HUMANCA2Homo sapiens

Carbonic anhydrase 2

Catalyzes the reversible hydration of carbon dioxide11327835,11802772,11831900,12056894,12171926,1336460,14736236,15300855,15453828,15667203,15865431,16106378,16214338,16290146,16686544,16759856,16807956,17127057,17251017,17314045,17330962,17346964,17540563,17588751,17705204,18024029,18162396,18266323,18374572,18481843,18618712,18640037,18942852,1909891,1910042,19170619,19186056,19206230,19520834,19778001,7761440,7901850,8218160,8262987,8399159,8451242,8485129,8639494,9265618,9398308. Can also hydrate cyanamide to urea10550681,11015219. Stimulates the chloride-bicarbonate exchange activity of SLC26A615990874. Essential for bone resorption and osteoclast differentiation15300855. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption

Quoted from UniProt’s FUNCTION annotation for P00918 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
SLC9A10.9540.2990.0000.938
SLC4A10.9190.7350.0000.675
SLC4A40.8930.0870.0000.880
TCIRG10.8710.0000.0000.869
ATP6V1B10.8410.0000.0000.838
CA10.8330.0000.7000.399
CBSL0.8190.0000.0000.819
CBS0.8190.0000.0000.819
CLCN70.8060.0000.0000.804
CYP24A10.7990.0000.0000.791

Where it sits in the cell

UniProt, curated Cytoplasm · Cell membrane

Expression by cell type

Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Foveolar cells3,491.7 nCPM
  • Colonocytes2,144.8 nCPM
  • Erythrocyte progenitors1,624.1 nCPM
  • Müller glia1,234.5 nCPM
  • Parietal cells809.7 nCPM
  • Platelets722.8 nCPM
  • Extravillous trophoblasts681.2 nCPM
  • Erythrocytes498.3 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • stomach 11,046.9 nTPM
  • choroid plexus944.3 nTPM
  • intestine644.2 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 78.1 nTPM, from CA2cerebellum — 11.3 nTPM, from CA2hippocampal formation — 98.7 nTPM, from CA2amygdala — 90.0 nTPM, from CA2hypothalamus — 56.5 nTPM, from CA2thalamus — no resolved target expressed herebasal ganglia — 133.6 nTPM, from CA2medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 361.8, spinal cord 105.2, midbrain 101.7, pituitary gland 6.4.

Body

heart — 17.2 nTPM, from CA2smooth muscle — 30.2 nTPM, from CA2lung — 40.6 nTPM, from CA2liver — 255.7 nTPM, from CA2kidney — 309.0 nTPM, from CA2stomach — 1046.9 nTPM, from CA2duodenum — 268.0 nTPM, from CA2small intestine — 29.6 nTPM, from CA2colon — 644.2 nTPM, from CA2adrenal gland — 11.4 nTPM, from CA2thyroid gland — 16.2 nTPM, from CA2pancreas — 52.0 nTPM, from CA2urinary bladder — 2.7 nTPM, from CA2skeletal muscle — 40.0 nTPM, from CA2spleen — 8.7 nTPM, from CA2salivary gland — 70.3 nTPM, from CA2
01047 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of CA2 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • retina361.8 nTPM
  • basal ganglia133.6 nTPM
  • spinal cord105.2 nTPM
  • midbrain101.7 nTPM
  • hippocampal formation98.7 nTPM
  • amygdala90.0 nTPM
  • cerebral cortex78.1 nTPM
  • hypothalamus56.5 nTPM
  • cerebellum11.3 nTPM
  • pituitary gland6.4 nTPM

Peripheral and autonomic · 16

  • stomach 11046.9 nTPM
  • colon644.2 nTPM
  • kidney309.0 nTPM
  • duodenum268.0 nTPM
  • liver255.7 nTPM
  • salivary gland70.3 nTPM
  • pancreas52.0 nTPM
  • lung40.6 nTPM
  • skeletal muscle40.0 nTPM
  • smooth muscle30.2 nTPM
  • small intestine29.6 nTPM
  • heart muscle17.2 nTPM
  • thyroid gland16.2 nTPM
  • adrenal gland11.4 nTPM
  • spleen8.7 nTPM
  • urinary bladder2.7 nTPM

Transcript is not protein. These are RNA levels for CA2, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
Carbonic anhydrase 2EnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Carbonic anhydrase 2EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
Carbonic anhydrase 2EnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909123
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