Calcium/calmodulin-dependent protein kinase kinase 2
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Calcium/calmodulin-dependent protein kinase kinase 2
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching
Quoted from UniProt’s FUNCTION annotation for Q96RR4 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| CALM3 | 0.999 | 0.343 | 0.900 | 0.985 |
| CALML3 | 0.998 | 0.072 | 0.900 | 0.980 |
| CALML5 | 0.998 | 0.072 | 0.900 | 0.980 |
| CALML6 | 0.997 | 0.045 | 0.900 | 0.978 |
| CALML4 | 0.997 | 0.045 | 0.900 | 0.978 |
| PRKAB2 | 0.975 | 0.256 | 0.900 | 0.697 |
| PRKAG1 | 0.975 | 0.427 | 0.900 | 0.567 |
| PRKAG2 | 0.975 | 0.301 | 0.900 | 0.663 |
| PRKAB1 | 0.973 | 0.352 | 0.900 | 0.607 |
| PRKAA2 | 0.964 | 0.503 | 0.900 | 0.347 |
Where it sits in the cell
- Cytosol
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus · Cytoplasm · Cell projection, neuron projection
Expression by cell type
Single cell type RNA, the 4 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Neutrophils716 nCPM
- Neutrophil progenitors249.8 nCPM
- Late spermatids160.6 nCPM
- monocytes114.3 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain324 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1052080 |
| Calcium/calmodulin-dependent protein kinase kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1052080 |
| Calcium/calmodulin-dependent protein kinase kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1052080 |
| Calcium/calmodulin-dependent protein kinase kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1052080 |