Calcium/calmodulin-dependent protein kinase kinase 1
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Calcium/calmodulin-dependent protein kinase kinase 1
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death
Quoted from UniProt’s FUNCTION annotation for Q8N5S9 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Cytosol
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Nucleus
Expression by cell type
Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Somatotrophs99.4 nCPM
- Sertoli cells91 nCPM
- Retinal bipolar cells80.9 nCPM
- Retinal ganglion cells73.4 nCPM
- Brain excitatory neurons64.6 nCPM
- Lactotrophs63.2 nCPM
- Neutrophils56.5 nCPM
- Adrenal medulla cells53.2 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain70.2 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase kinase 1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061198 |
| Calcium/calmodulin-dependent protein kinase kinase 1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061198 |
| Calcium/calmodulin-dependent protein kinase kinase 1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061198 |
| Calcium/calmodulin-dependent protein kinase kinase 1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1061198 |