C5a anaphylatoxin chemotactic receptor 1
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 7
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
C5a anaphylatoxin chemotactic receptor 1
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production10636859,15153520,1847994,29300009,36806352,7622471,8182049,9553099. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase36806352,37852260. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase36806352,37852260. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events7622471,8182049,9553099
Quoted from UniProt’s FUNCTION annotation for P21730 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Golgi apparatus
- Vesiclesadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Cytoplasmic vesicle
Expression by cell type
Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Neutrophils2,460.4 nCPM
- monocytes1,285.2 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- bone marrow118.4 nTPM
- lymphoid tissue80 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 7
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| C5a anaphylatoxin chemotactic receptor 1 | Other named receptors | %Max (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209817 |
| C5a anaphylatoxin chemotactic receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209817 |
| C5a anaphylatoxin chemotactic receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209817 |
| C5a anaphylatoxin chemotactic receptor 1 | Other named receptors | %Max (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209817 |
| C5a anaphylatoxin chemotactic receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209817 |
| C5a anaphylatoxin chemotactic receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209818 |
| C5a anaphylatoxin chemotactic receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209819 |