Skip to content
PsychedeliaDokholyan Laboratory
TargetOther named receptors

C-C chemokine receptor type 5

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements
14
Compounds
7
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

CCR5_HUMANCCR5Homo sapiens

C-C chemokine receptor type 5

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor30713770
(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1

Quoted from UniProt’s FUNCTION annotation for P51681 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
CCL3L10.9990.5100.9000.997
CCL80.9990.2870.9000.993
CCL50.9990.9820.9000.999
ITIH40.9990.0000.0000.999
CD40.9990.9570.0000.999
CCL40.9990.9940.9000.999
CCL20.9990.3090.6500.997
CCL30.9990.5100.9000.999
CXCL100.9990.0000.6500.997
CCL110.9980.2870.6500.995

Where it sits in the cell

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 5 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • cDC21.5 nCPM
  • T-cells19.4 nCPM
  • pDCs15.8 nCPM
  • monocytes15.2 nCPM
  • Macrophages13.5 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • lymphoid tissue14.5 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 1.2 nTPM, from CCR5cerebellum — no resolved target expressed herehippocampal formation — 0.3 nTPM, from CCR5amygdala — 0.4 nTPM, from CCR5hypothalamus — 0.4 nTPM, from CCR5thalamus — no resolved target expressed herebasal ganglia — 0.3 nTPM, from CCR5medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: spinal cord 1.2, midbrain 0.7, pituitary gland 0.4, retina 0.1.

Body

heart — 1.0 nTPM, from CCR5smooth muscle — 3.1 nTPM, from CCR5lung — 7.1 nTPM, from CCR5liver — 3.2 nTPM, from CCR5kidney — 1.0 nTPM, from CCR5stomach — 6.6 nTPM, from CCR5duodenum — 4.0 nTPM, from CCR5small intestine — 5.7 nTPM, from CCR5colon — 3.2 nTPM, from CCR5adrenal gland — 1.9 nTPM, from CCR5thyroid gland — 0.8 nTPM, from CCR5pancreas — 0.6 nTPM, from CCR5urinary bladder — 4.6 nTPM, from CCR5skeletal muscle — 0.3 nTPM, from CCR5spleen — 9.1 nTPM, from CCR5salivary gland — 2.8 nTPM, from CCR5
09 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of CCR5 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 9

  • cerebral cortex1.2 nTPM
  • spinal cord1.2 nTPM
  • midbrain0.7 nTPM
  • amygdala0.4 nTPM
  • hypothalamus0.4 nTPM
  • pituitary gland0.4 nTPM
  • hippocampal formation0.3 nTPM
  • basal ganglia0.3 nTPM
  • retina0.1 nTPM

Peripheral and autonomic · 16

  • spleen9.1 nTPM
  • lung7.1 nTPM
  • stomach 16.6 nTPM
  • small intestine5.7 nTPM
  • urinary bladder4.6 nTPM
  • duodenum4.0 nTPM
  • liver3.2 nTPM
  • colon3.2 nTPM
  • smooth muscle3.1 nTPM
  • salivary gland2.8 nTPM
  • adrenal gland1.9 nTPM
  • heart muscle1.0 nTPM
  • kidney1.0 nTPM
  • thyroid gland0.8 nTPM
  • pancreas0.6 nTPM
  • skeletal muscle0.3 nTPM

Transcript is not protein. These are RNA levels for CCR5, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
C-C chemokine receptor type 5Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
C-C chemokine receptor type 5Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
C-C chemokine receptor type 5Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909126
← All targets