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PsychedeliaDokholyan Laboratory
TargetOther named receptors

B2 bradykinin receptor

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements
20
Compounds
10
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

BKRB2_HUMANBDKRB2Homo sapiens

B2 bradykinin receptor

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

Quoted from UniProt’s FUNCTION annotation for P30411 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
KNG10.9990.9940.9000.999
AGT0.9890.0000.9000.900
GNAQ0.9820.1150.9000.814
AGTR10.9750.2870.4000.945
BDKRB10.9690.0000.9000.500
GNB10.9520.9090.5000.000
EDN10.9350.1280.9000.301
GNA110.9250.1150.9000.197
GNA150.9210.1150.9000.181
ACE0.9170.3220.0000.883

Where it sits in the cell

  • Plasma membrane
  • Vesiclesadditional
  • Cytokinetic bridgeadditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Ependymal cells5.5 nCPM
  • Brain excitatory neurons4.4 nCPM
  • Oligodendrocytes2.8 nCPM
  • Choroid plexus epithelial cells2.2 nCPM
  • Esophageal apical cells1.6 nCPM
  • Enterocytes1 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • urinary bladder38.4 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 1.0 nTPM, from BDKRB2cerebellum — 3.2 nTPM, from BDKRB2hippocampal formation — 0.5 nTPM, from BDKRB2amygdala — 0.5 nTPM, from BDKRB2hypothalamus — 0.4 nTPM, from BDKRB2thalamus — no resolved target expressed herebasal ganglia — 0.5 nTPM, from BDKRB2medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 0.8, midbrain 0.6, spinal cord 0.4.

Body

heart — 1.2 nTPM, from BDKRB2smooth muscle — 9.5 nTPM, from BDKRB2lung — 2.4 nTPM, from BDKRB2liver — 0.7 nTPM, from BDKRB2kidney — 10.9 nTPM, from BDKRB2stomach — 4.7 nTPM, from BDKRB2duodenum — 7.5 nTPM, from BDKRB2small intestine — 9.4 nTPM, from BDKRB2colon — 11.6 nTPM, from BDKRB2adrenal gland — 1.4 nTPM, from BDKRB2thyroid gland — 3.4 nTPM, from BDKRB2pancreas — 8.9 nTPM, from BDKRB2urinary bladder — 38.4 nTPM, from BDKRB2skeletal muscle — 0.9 nTPM, from BDKRB2spleen — 0.1 nTPM, from BDKRB2salivary gland — 3.2 nTPM, from BDKRB2
038 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of BDKRB2 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 9

  • cerebellum3.2 nTPM
  • cerebral cortex1.0 nTPM
  • pituitary gland0.8 nTPM
  • midbrain0.6 nTPM
  • hippocampal formation0.5 nTPM
  • amygdala0.5 nTPM
  • basal ganglia0.5 nTPM
  • hypothalamus0.4 nTPM
  • spinal cord0.4 nTPM

Peripheral and autonomic · 16

  • urinary bladder38.4 nTPM
  • colon11.6 nTPM
  • kidney10.9 nTPM
  • smooth muscle9.5 nTPM
  • small intestine9.4 nTPM
  • pancreas8.9 nTPM
  • duodenum7.5 nTPM
  • stomach 14.7 nTPM
  • thyroid gland3.4 nTPM
  • salivary gland3.2 nTPM
  • lung2.4 nTPM
  • adrenal gland1.4 nTPM
  • heart muscle1.2 nTPM
  • skeletal muscle0.9 nTPM
  • liver0.7 nTPM
  • spleen0.1 nTPM

Transcript is not protein. These are RNA levels for BDKRB2, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
B2 bradykinin receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100

Functional readouts 13

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
B2 bradykinin receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291753
B2 bradykinin receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
B2 bradykinin receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291753
B2 bradykinin receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291753
B2 bradykinin receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291753
B2 bradykinin receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291753
B2 bradykinin receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291753
B2 bradykinin receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909100
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