B1 bradykinin receptor
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 5
- Compounds
- 5
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
B1 bradykinin receptor
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation
Quoted from UniProt’s FUNCTION annotation for P46663 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 9 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Esophageal apical cells94.3 nCPM
- Basal keratinocytes36.6 nCPM
- Esophageal suprabasal cells24.8 nCPM
- Fibroblasts22.8 nCPM
- Epicardial cells22.7 nCPM
- Esophageal basal cells19.3 nCPM
- Suprabasal keratinocytes17.8 nCPM
- Epididymal basal cells13.6 nCPM
- Decidual stromal cells12.2 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- urinary bladder21.8 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 5
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| B1 bradykinin receptor | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291752 |
| B1 bradykinin receptor | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291752 |
| B1 bradykinin receptor | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291752 |
| B1 bradykinin receptor | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291752 |
| B1 bradykinin receptor | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291752 |