Aurora kinase A

Aurora kinase A

Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression11039908,12390251,17125279,17360485,18615013,26246606. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis14523000,26246606. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase27335426. Required for initial activation of CDK1 at centrosomes13678582,15128871. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX211551964,14702041,15128871,15147269,15987997,17604723,18056443,18615013. Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression27192185. Regulates KIF2A tubulin depolymerase activity19351716. Important for microtubule formation and/or stabilization18056443. Required for normal axon formation19812038. Plays a role in microtubule remodeling during neurite extension19668197. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP5314702041. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity11551964. Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin17604723,20643351. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP128218735

Quoted from UniProt’s FUNCTION annotation for O14965 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Where it sits in the cell

• Mitotic spindle
• Centrosome
• Basal body
• Nucleoplasmadditional
• Cytosoladditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · Cytoplasm, cytoskeleton, spindle pole · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole · Cell projection, neuron projection · Cell projection, cilium · Cytoplasm, cytoskeleton, cilium basal body · Basolateral cell membrane

Expression by cell type

Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

• Oocytes354.6 nCPM
• Late primary spermatocytes269.3 nCPM
• Monocyte progenitors90 nCPM
• Extravillous trophoblasts77.4 nCPM
• Erythrocyte progenitors61.8 nCPM
• Migrating cytotrophoblasts57.4 nCPM
• Differentiating spermatogonia49.5 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

• testis28.8 nTPM
• lymphoid tissue20.6 nTPM