ATP-dependent translocase ABCB1
SLC and ABC transporters governing uptake and efflux — distinct from the monoamine transporters.
- Measurements
- 25
- Compounds
- 8
- Binding constants
- 16
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
ATP-dependent translocase ABCB1
Translocates drugs and phospholipids across the membrane2897240,35970996,8898203,9038218,35507548. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins8898203. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells2897240,35970996,9038218
Quoted from UniProt’s FUNCTION annotation for P08183 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| CYP3A5 | 0.920 | 0.050 | 0.000 | 0.913 |
| IGKV2D-29 | 0.907 | 0.907 | 0.000 | 0.000 |
| CYP3A4 | 0.886 | 0.050 | 0.000 | 0.876 |
| SLCO1B1 | 0.883 | 0.000 | 0.000 | 0.877 |
| CYP2C19 | 0.858 | 0.069 | 0.000 | 0.850 |
| SLCO1B3 | 0.844 | 0.000 | 0.000 | 0.836 |
| NR1I2 | 0.842 | 0.000 | 0.000 | 0.832 |
| ABCF2-2 | 0.812 | 0.071 | 0.000 | 0.803 |
| ABCF2 | 0.812 | 0.071 | 0.000 | 0.803 |
| PPIG | 0.809 | 0.068 | 0.000 | 0.802 |
Where it sits in the cell
- Plasma membrane
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Apical cell membrane · Cytoplasm
Expression by cell type
Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Adrenal cortex cells747.9 nCPM
- Hematopoietic stem cells640 nCPM
- Enterocytes630.7 nCPM
- Vascular endothelial cells507.4 nCPM
- Colonocytes256 nCPM
- NK-cells216.6 nCPM
- Thymocytes162.6 nCPM
- Innate lymphoid cells147.7 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- adrenal gland96.1 nTPM
- intestine66.6 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 16
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076230 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076230 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076230 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076230 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076229 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076229 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076229 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076229 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL2076224 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL2076224 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL2076224 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL2076224 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL2076225 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL2076225 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL2076225 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ki | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL2076225 |
Other measurements 9
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Drug transporters | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076240 |
| ATP-dependent translocase ABCB1 | Drug transporters | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2075640 |
| ATP-dependent translocase ABCB1 | Drug transporters | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076203 |
| ATP-dependent translocase ABCB1 | Drug transporters | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076203 |
| ATP-dependent translocase ABCB1 | Drug transporters | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2076203 |
| ATP-dependent translocase ABCB1 | Drug transporters | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2075633 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL827620 |
| ATP-dependent translocase ABCB1 | Drug transporters | Transport | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL825762 |
| ATP-dependent translocase ABCB1 | Drug transporters | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL884551 |