ATP-dependent DNA helicase Q1
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 8
- Compounds
- 5
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
ATP-dependent DNA helicase Q1
DNA helicase that plays a role in DNA damage repair and genome stability15886194,35025765,7527136,7961977,8056767. Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction19151156,35025765,7527136,8056767. Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity19151156,25831490. Plays a role in restoring regressed replication forks35025765. Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions35025765. Does not unwind G-quadruplex DNA18426915. May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens15886194,7961977
Quoted from UniProt’s FUNCTION annotation for P46063 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nucleoplasm
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus
Expression by cell type
Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Megakaryocytes148.4 nCPM
- Esophageal apical cells118.4 nCPM
II · Anatomy
Where the gene is transcribed
The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.
Brain
basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.
Measured but not drawn — this anatomogram has no outline for them: retina 9.1, spinal cord 7.1, midbrain 5.7, pituitary gland 4.7.
Body
Square-root ramp · shared scale across both plates
Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of RECQL transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.
Brain · 10
- retina9.1 nTPM
- cerebral cortex8.1 nTPM
- spinal cord7.1 nTPM
- midbrain5.7 nTPM
- basal ganglia5.0 nTPM
- cerebellum4.7 nTPM
- hippocampal formation4.7 nTPM
- pituitary gland4.7 nTPM
- amygdala4.5 nTPM
- hypothalamus4.2 nTPM
Peripheral and autonomic · 16
- spleen29.7 nTPM
- smooth muscle28.3 nTPM
- heart muscle25.2 nTPM
- urinary bladder24.4 nTPM
- lung21.5 nTPM
- adrenal gland16.2 nTPM
- thyroid gland15.5 nTPM
- liver14.7 nTPM
- colon14.0 nTPM
- kidney13.9 nTPM
- stomach 113.7 nTPM
- small intestine12.7 nTPM
- skeletal muscle11.5 nTPM
- duodenum10.7 nTPM
- salivary gland9.5 nTPM
- pancreas9.3 nTPM
Transcript is not protein. These are RNA levels for RECQL, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 8
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| ATP-dependent DNA helicase Q1 | Enzymes | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1613829 |
| ATP-dependent DNA helicase Q1 | Enzymes | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1613829 |
| ATP-dependent DNA helicase Q1 | Enzymes | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1613829 |
| ATP-dependent DNA helicase Q1 | Enzymes | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1613829 |
| ATP-dependent DNA helicase Q1 | Enzymes | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1613829 |
| ATP-dependent DNA helicase Q1 | Enzymes | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1794433 |
| ATP-dependent DNA helicase Q1 | Enzymes | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1613928 |
| ATP-dependent DNA helicase Q1 | Enzymes | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1614330 |