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PsychedeliaDokholyan Laboratory
TargetEnzymes

Arylsulfatase A

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
8
Compounds
8
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

ARSA_HUMANARSAHomo sapiens

Arylsulfatase A

Lysosomal enzyme that catalyzes the hydrolysis of cerebroside-3-sulfate (sulfatide) into cerebroside and sulfate, a reaction that requires the activator protein saposin B

Quoted from UniProt’s FUNCTION annotation for P15289 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
GALC0.9850.0000.9000.859
GLA0.9740.0000.9000.753
SUMF10.9570.4010.5000.780
ARSB0.9500.0650.9000.389
UGT80.9480.0000.9000.507
ARSG0.9240.0000.9000.191
NEU10.9230.0000.9000.262
NEU40.9160.0460.9000.193
PSAP0.9130.0000.0000.911
NEU30.9050.0460.9000.086

Where it sits in the cell

  • Golgi apparatus
  • Cytosoladditional
  • Mid pieceadditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Endoplasmic reticulum · Lysosome

Expression by cell type

Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Late spermatids215.5 nCPM
  • Fallopian tube ciliated cells103.1 nCPM
  • Enterocytes90.4 nCPM
  • Breast lactating cells85.3 nCPM
  • Plasma cells85.3 nCPM
  • Late primary spermatocytes84.5 nCPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 18.9 nTPM, from ARSAcerebellum — 23.6 nTPM, from ARSAhippocampal formation — 15.8 nTPM, from ARSAamygdala — 14.0 nTPM, from ARSAhypothalamus — 14.5 nTPM, from ARSAthalamus — no resolved target expressed herebasal ganglia — 16.8 nTPM, from ARSAmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 34.9, spinal cord 22.8, midbrain 17.7, retina 4.0.

Body

heart — 31.1 nTPM, from ARSAsmooth muscle — 6.1 nTPM, from ARSAlung — 28.2 nTPM, from ARSAliver — 41.7 nTPM, from ARSAkidney — 30.5 nTPM, from ARSAstomach — 28.7 nTPM, from ARSAduodenum — 29.0 nTPM, from ARSAsmall intestine — 32.6 nTPM, from ARSAcolon — 29.9 nTPM, from ARSAadrenal gland — 23.7 nTPM, from ARSAthyroid gland — 32.4 nTPM, from ARSApancreas — 44.1 nTPM, from ARSAurinary bladder — 23.8 nTPM, from ARSAskeletal muscle — 22.0 nTPM, from ARSAspleen — 44.1 nTPM, from ARSAsalivary gland — 37.9 nTPM, from ARSA
044 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of ARSA transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • pituitary gland34.9 nTPM
  • cerebellum23.6 nTPM
  • spinal cord22.8 nTPM
  • cerebral cortex18.9 nTPM
  • midbrain17.7 nTPM
  • basal ganglia16.8 nTPM
  • hippocampal formation15.8 nTPM
  • hypothalamus14.5 nTPM
  • amygdala14.0 nTPM
  • retina4.0 nTPM

Peripheral and autonomic · 16

  • pancreas44.1 nTPM
  • spleen44.1 nTPM
  • liver41.7 nTPM
  • salivary gland37.9 nTPM
  • small intestine32.6 nTPM
  • thyroid gland32.4 nTPM
  • heart muscle31.1 nTPM
  • kidney30.5 nTPM
  • colon29.9 nTPM
  • duodenum29.0 nTPM
  • stomach 128.7 nTPM
  • lung28.2 nTPM
  • urinary bladder23.8 nTPM
  • adrenal gland23.7 nTPM
  • skeletal muscle22.0 nTPM
  • smooth muscle6.1 nTPM

Transcript is not protein. These are RNA levels for ARSA, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 8

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Arylsulfatase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL3215185
Arylsulfatase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL3215185
Arylsulfatase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL3215185
Arylsulfatase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL3215185
Arylsulfatase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL3215185
Arylsulfatase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL3215185
Arylsulfatase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL3215185
Arylsulfatase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL3215185
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