Skip to content
PsychedeliaDokholyan Laboratory
TargetEnzymes

Amine oxidase [flavin-containing] A

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
71
Compounds
33
Binding constants
14
Median pX
7.19

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

AOFA_HUMANMAOAHomo sapiens

Amine oxidase [flavin-containing] A

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues18391214,20493079,24169519,8316221. Preferentially oxidizes serotonin20493079,24169519. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity)

Quoted from UniProt’s FUNCTION annotation for P21397 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
COMT0.9960.0000.9100.963
LRTOMT0.9890.0000.9080.893
DBH0.9870.0000.9000.876
DDC0.9860.0670.9000.863
ALDH20.9820.0000.9180.780
AOC20.9800.0000.9000.798
AOC10.9700.0000.9000.700
MAOB0.9650.6090.9000.063
CYP2D60.9630.0000.9000.641
AOC30.9590.0000.9000.572

Where it sits in the cell

  • Mitochondria
  • Cytosoladditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Mitochondrion outer membrane

Expression by cell type

Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Enterocytes920 nCPM
  • Alveolar cells type 2420.3 nCPM
  • Basal prostatic cells402.5 nCPM
  • Syncytiotrophoblasts391.3 nCPM
  • Adipocytes378.3 nCPM
  • Enteric transient amplifying cells357 nCPM
  • Medullary thymic epithelial cells355.2 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • intestine206.3 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 20.0 nTPM, from MAOAcerebellum — 4.0 nTPM, from MAOAhippocampal formation — 14.8 nTPM, from MAOAamygdala — 21.5 nTPM, from MAOAhypothalamus — 21.2 nTPM, from MAOAthalamus — no resolved target expressed herebasal ganglia — 22.0 nTPM, from MAOAmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: midbrain 34.6, retina 24.3, spinal cord 7.9, pituitary gland 3.4.

Body

heart — 44.8 nTPM, from MAOAsmooth muscle — 21.4 nTPM, from MAOAlung — 56.9 nTPM, from MAOAliver — 103.3 nTPM, from MAOAkidney — 69.7 nTPM, from MAOAstomach — 50.0 nTPM, from MAOAduodenum — 143.7 nTPM, from MAOAsmall intestine — 206.3 nTPM, from MAOAcolon — 104.7 nTPM, from MAOAadrenal gland — 24.9 nTPM, from MAOAthyroid gland — 105.7 nTPM, from MAOApancreas — 35.0 nTPM, from MAOAurinary bladder — 61.9 nTPM, from MAOAskeletal muscle — 29.0 nTPM, from MAOAspleen — 5.6 nTPM, from MAOAsalivary gland — 66.9 nTPM, from MAOA
0206 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of MAOA transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • midbrain34.6 nTPM
  • retina24.3 nTPM
  • basal ganglia22.0 nTPM
  • amygdala21.5 nTPM
  • hypothalamus21.2 nTPM
  • cerebral cortex20.0 nTPM
  • hippocampal formation14.8 nTPM
  • spinal cord7.9 nTPM
  • cerebellum4.0 nTPM
  • pituitary gland3.4 nTPM

Peripheral and autonomic · 16

  • small intestine206.3 nTPM
  • duodenum143.7 nTPM
  • thyroid gland105.7 nTPM
  • colon104.7 nTPM
  • liver103.3 nTPM
  • kidney69.7 nTPM
  • salivary gland66.9 nTPM
  • urinary bladder61.9 nTPM
  • lung56.9 nTPM
  • stomach 150.0 nTPM
  • heart muscle44.8 nTPM
  • pancreas35.0 nTPM
  • skeletal muscle29.0 nTPM
  • adrenal gland24.9 nTPM
  • smooth muscle21.4 nTPM
  • spleen5.6 nTPM

Transcript is not protein. These are RNA levels for MAOA, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

III · Ranking

Compounds by strongest binding constant

One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.

  1. 01Harmine9.00
  2. 02p-Methoxyamphetamine6.60
  3. 034-Methylthioamphetamine6.60
  4. 04Norharman6.59

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 14

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
Amine oxidase [flavin-containing] AEnzymesKi1.009.00Homo sapiensCHEMBL5235560
Amine oxidase [flavin-containing] AEnzymesKi5.008.30Homo sapiensCHEMBL1074724
Amine oxidase [flavin-containing] AEnzymesKi17.007.77Homo sapiensCHEMBL1817453
Amine oxidase [flavin-containing] AEnzymesKi2506.60Rattus norvegicusCHEMBL1022171
Amine oxidase [flavin-containing] AEnzymesKi2506.60Rattus norvegicusCHEMBL1022171
Amine oxidase [flavin-containing] AEnzymesKi2606.59Homo sapiensCHEMBL4125431
Amine oxidase [flavin-containing] AEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1648260
Amine oxidase [flavin-containing] AEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169

Functional readouts 49

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Amine oxidase [flavin-containing] AEnzymesIC501.009.00Homo sapiensCHEMBL5235559
Amine oxidase [flavin-containing] AEnzymesIC502.508.60Homo sapiensCHEMBL5235559
Amine oxidase [flavin-containing] AEnzymesIC504.108.39Homo sapiensCHEMBL5217003
Amine oxidase [flavin-containing] AEnzymesIC504.108.39Homo sapiensCHEMBL5249365
Amine oxidase [flavin-containing] AEnzymesIC504.108.39Homo sapiensCHEMBL5152643
Amine oxidase [flavin-containing] AEnzymesIC505.008.30Homo sapiensCHEMBL5105891
Amine oxidase [flavin-containing] AEnzymesIC5012.007.92Rattus norvegicusCHEMBL733230
Amine oxidase [flavin-containing] AEnzymesIC5029.007.54Homo sapiensCHEMBL5235559
Amine oxidase [flavin-containing] AEnzymesIC5042.007.38Homo sapiensCHEMBL5638932
Amine oxidase [flavin-containing] AEnzymesIC5060.007.22Homo sapiensCHEMBL6118154
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291830
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291830
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291830
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291830
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291830
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5235559
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4711820
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909169
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291895
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554
Amine oxidase [flavin-containing] AEnzymesIC50— no normalized value— value does not convert to pXRattus norvegicusCHEMBL828554

Other measurements 8

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

TargetClassTypeValue (nM)pXOrganismAssay
Amine oxidase [flavin-containing] AEnzymesInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4344366
Amine oxidase [flavin-containing] AEnzymesActivity— no normalized value— value does not convert to pXMus musculusCHEMBL965578
Amine oxidase [flavin-containing] AEnzymesActivity— no normalized value— value does not convert to pXMus musculusCHEMBL965578
Amine oxidase [flavin-containing] AEnzymesActivity— no normalized value— value does not convert to pXMus musculusCHEMBL965578
Amine oxidase [flavin-containing] AEnzymesInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL836152
Amine oxidase [flavin-containing] AEnzymesInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL836156
Amine oxidase [flavin-containing] AEnzymesInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL834910
Amine oxidase [flavin-containing] AEnzymesInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL834908
← All targets