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PsychedeliaDokholyan Laboratory
TargetEnzymes

Alpha-galactosidase A

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
2
Compounds
2
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

AGAL_HUMANGLAHomo sapiens

Alpha-galactosidase A

Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome

Quoted from UniProt’s FUNCTION annotation for P06280 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
GLB10.9840.0000.9000.800
GALC0.9760.0000.9000.771
ARSA0.9740.0000.9000.753
MGAM0.9730.0000.9000.742
SI0.9720.0000.9000.736
A4GALT0.9490.0000.9000.511
GAA0.9430.0000.9000.457
HEXB0.9410.0000.9000.336
HEXA0.9390.0000.9000.383
MGAM20.9340.0000.9000.374

Where it sits in the cell

UniProt, curated Lysosome

Expression by cell type

Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Platelets427.4 nCPM
  • cDC332 nCPM
  • Plasma cells265.2 nCPM
  • Syncytiotrophoblasts209.7 nCPM
  • Neutrophils206.9 nCPM
  • Macrophages179.2 nCPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 5.1 nTPM, from GLAcerebellum — 4.4 nTPM, from GLAhippocampal formation — 4.5 nTPM, from GLAamygdala — 4.4 nTPM, from GLAhypothalamus — 5.4 nTPM, from GLAthalamus — no resolved target expressed herebasal ganglia — 5.6 nTPM, from GLAmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 9.1, midbrain 7.0, spinal cord 6.6, retina 6.4.

Body

heart — 9.3 nTPM, from GLAsmooth muscle — 14.4 nTPM, from GLAlung — 16.2 nTPM, from GLAliver — 11.9 nTPM, from GLAkidney — 14.5 nTPM, from GLAstomach — 8.8 nTPM, from GLAduodenum — 21.1 nTPM, from GLAsmall intestine — 12.7 nTPM, from GLAcolon — 12.2 nTPM, from GLAadrenal gland — 20.7 nTPM, from GLAthyroid gland — 7.3 nTPM, from GLApancreas — 6.8 nTPM, from GLAurinary bladder — 13.7 nTPM, from GLAskeletal muscle — 5.4 nTPM, from GLAspleen — 12.7 nTPM, from GLAsalivary gland — 9.4 nTPM, from GLA
021 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of GLA transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • pituitary gland9.1 nTPM
  • midbrain7.0 nTPM
  • spinal cord6.6 nTPM
  • retina6.4 nTPM
  • basal ganglia5.6 nTPM
  • hypothalamus5.4 nTPM
  • cerebral cortex5.1 nTPM
  • hippocampal formation4.5 nTPM
  • cerebellum4.4 nTPM
  • amygdala4.4 nTPM

Peripheral and autonomic · 16

  • duodenum21.1 nTPM
  • adrenal gland20.7 nTPM
  • lung16.2 nTPM
  • kidney14.5 nTPM
  • smooth muscle14.4 nTPM
  • urinary bladder13.7 nTPM
  • small intestine12.7 nTPM
  • spleen12.7 nTPM
  • colon12.2 nTPM
  • liver11.9 nTPM
  • salivary gland9.4 nTPM
  • heart muscle9.3 nTPM
  • stomach 18.8 nTPM
  • thyroid gland7.3 nTPM
  • pancreas6.8 nTPM
  • skeletal muscle5.4 nTPM

Transcript is not protein. These are RNA levels for GLA, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 2

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Alpha-galactosidase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614217
Alpha-galactosidase AEnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614217
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