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PsychedeliaDokholyan Laboratory
TargetAdrenergic receptors

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

α and β adrenoceptors.

Measurements
2
Compounds
1
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

MGAT2_HUMANMGAT2Homo sapiens

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans

Quoted from UniProt’s FUNCTION annotation for Q10469 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
MAN2A10.9780.0000.9000.789
MAN2A20.9710.0000.9000.726
MGAT30.9700.0000.9000.716
MGAT4B0.9680.0000.9000.692
FUT80.9680.0000.9000.677
MGAT4A0.9670.0000.9000.692
MGAT4D0.9440.0000.9000.465
MGAT10.9430.0000.0000.942
MGAT50.7890.0000.0000.784
POMGNT10.6540.0000.0000.654

Where it sits in the cell

  • Golgi apparatus

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Golgi apparatus membrane

Expression by cell type

Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Hepatocytes71.1 nCPM
  • Plasma cells68.4 nCPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 7.5 nTPM, from MGAT2cerebellum — 6.2 nTPM, from MGAT2hippocampal formation — 5.0 nTPM, from MGAT2amygdala — 5.1 nTPM, from MGAT2hypothalamus — 5.6 nTPM, from MGAT2thalamus — no resolved target expressed herebasal ganglia — 5.9 nTPM, from MGAT2medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 7.6, pituitary gland 7.4, spinal cord 5.4, midbrain 5.2.

Body

heart — 10.9 nTPM, from MGAT2smooth muscle — 14.9 nTPM, from MGAT2lung — 13.0 nTPM, from MGAT2liver — 38.1 nTPM, from MGAT2kidney — 13.2 nTPM, from MGAT2stomach — 19.8 nTPM, from MGAT2duodenum — 21.7 nTPM, from MGAT2small intestine — 21.2 nTPM, from MGAT2colon — 22.1 nTPM, from MGAT2adrenal gland — 16.4 nTPM, from MGAT2thyroid gland — 12.5 nTPM, from MGAT2pancreas — 22.2 nTPM, from MGAT2urinary bladder — 19.5 nTPM, from MGAT2skeletal muscle — 4.7 nTPM, from MGAT2spleen — 19.0 nTPM, from MGAT2salivary gland — 14.9 nTPM, from MGAT2
038 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of MGAT2 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • retina7.6 nTPM
  • cerebral cortex7.5 nTPM
  • pituitary gland7.4 nTPM
  • cerebellum6.2 nTPM
  • basal ganglia5.9 nTPM
  • hypothalamus5.6 nTPM
  • spinal cord5.4 nTPM
  • midbrain5.2 nTPM
  • amygdala5.1 nTPM
  • hippocampal formation5.0 nTPM

Peripheral and autonomic · 16

  • liver38.1 nTPM
  • pancreas22.2 nTPM
  • colon22.1 nTPM
  • duodenum21.7 nTPM
  • small intestine21.2 nTPM
  • stomach 119.8 nTPM
  • urinary bladder19.5 nTPM
  • spleen19.0 nTPM
  • adrenal gland16.4 nTPM
  • smooth muscle14.9 nTPM
  • salivary gland14.9 nTPM
  • kidney13.2 nTPM
  • lung13.0 nTPM
  • thyroid gland12.5 nTPM
  • heart muscle10.9 nTPM
  • skeletal muscle4.7 nTPM

Transcript is not protein. These are RNA levels for MGAT2, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 2

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseAdrenergic receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4845048
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseAdrenergic receptorsIC50— no normalized value— value does not convert to pXMus musculusCHEMBL4845049
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