TargetAdrenergic receptors

Alpha-1

α and β adrenoceptors.

Measurements: 38
Compounds: 17
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

No single gene answers to Alpha-1. Names like this one are families or unsubtyped preparations — a measurement made against whatever receptors a tissue carried, before or without resolving which subtype bound the compound. A family has no one accession, and picking a member to stand for it would invent a precision the assay never had: asked for “Muscarinic acetylcholine receptor” UniProt returns CHRM1, and that answer is wrong.

Resolver said no gene lists this target name as a synonym — recorded by tools/fetch_expression.py, not written here.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 34

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Alpha-1	Adrenergic receptors	EC50	537	6.27	Homo sapiens	CHEMBL3370251
Alpha-1	Adrenergic receptors	EC50	540	6.27	Homo sapiens	CHEMBL3370251
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291796
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291796
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291796
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291796
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291796
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291797
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291797
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291797
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291797
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291797
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291799
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291799
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5291799
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291798
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291798
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291798
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291798
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291798
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291798
Alpha-1	Adrenergic receptors	EC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL2317989
Alpha-1	Adrenergic receptors	EC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL2317989
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291800
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291800
Alpha-1	Adrenergic receptors	AC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL5291801

Show all 34 rowsShow first 20

Other measurements 4

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Alpha-1	Adrenergic receptors	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1052116
Alpha-1	Adrenergic receptors	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1052116
Alpha-1	Adrenergic receptors	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1052116
Alpha-1	Adrenergic receptors	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1052116

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